Spatiotemporal profiling of antibiotics and resistance genes in a river catchment: Human population as the main driver of antibiotic and antibiotic resistance gene presence in the environment
•4 AB classes and 4 ARGs in 5 WWTPs serving 5 cities studied.•Strong positive correlation observed between AB, ARG daily loads and population size.•The removal of ABs and ARGs is site and target specific and highly variable.•Some evidence that selection for sul1 and qnrS occurs during wastewater tre...
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Published in | Water research (Oxford) Vol. 203; p. 117533 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
15.09.2021
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Abstract | •4 AB classes and 4 ARGs in 5 WWTPs serving 5 cities studied.•Strong positive correlation observed between AB, ARG daily loads and population size.•The removal of ABs and ARGs is site and target specific and highly variable.•Some evidence that selection for sul1 and qnrS occurs during wastewater treatment.•PNEC exceeded for ciprofloxacin, clarithromycin, azithromycin, erythromycin.
Studies to understand the role wastewater treatment plants (WWTPs) play in the dissemination of antibiotics (ABs), and in the emergence of antibiotic resistance (ABR), play an important role in tackling this global crisis. Here we describe the abundance and distribution of 16 ABs, and 4 corresponding antibiotic resistance genes (ARGs), sampled from the influent to five WWTPs within a single river catchment. We consider four classes of antibiotics: fluroquinolones, macrolides, sulfamethoxazole and chloramphenicol, as well the corresponding antibiotic resistance genes qnrS, ermB, sul1 and catA. All antibiotics, apart from four fluroquinolones (besifloxacin, lomefloxacin, ulifloxacin, prulifloxacin), were detected within all influent wastewater from the 5 cities (1 city = 1 WWTP), as were the corresponding antibiotic resistance genes (ARGs). Strong correlations were observed between the daily loads of ABs and ARGs versus the size of the population served by each WWTP, as well as between AB and ARG loads at a single site. The efficiency of ABs and ARGs removal by the WWTPs varied according to site (and treatment process utilized) and target, although strong correlations were maintained between the population size served by WWTPs and daily loads of discharged ABs and ARGs into the environment. We therefore conclude that population size is the main determinant of the magnitude of AB and ARG burden in the environment.
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AbstractList | •4 AB classes and 4 ARGs in 5 WWTPs serving 5 cities studied.•Strong positive correlation observed between AB, ARG daily loads and population size.•The removal of ABs and ARGs is site and target specific and highly variable.•Some evidence that selection for sul1 and qnrS occurs during wastewater treatment.•PNEC exceeded for ciprofloxacin, clarithromycin, azithromycin, erythromycin.
Studies to understand the role wastewater treatment plants (WWTPs) play in the dissemination of antibiotics (ABs), and in the emergence of antibiotic resistance (ABR), play an important role in tackling this global crisis. Here we describe the abundance and distribution of 16 ABs, and 4 corresponding antibiotic resistance genes (ARGs), sampled from the influent to five WWTPs within a single river catchment. We consider four classes of antibiotics: fluroquinolones, macrolides, sulfamethoxazole and chloramphenicol, as well the corresponding antibiotic resistance genes qnrS, ermB, sul1 and catA. All antibiotics, apart from four fluroquinolones (besifloxacin, lomefloxacin, ulifloxacin, prulifloxacin), were detected within all influent wastewater from the 5 cities (1 city = 1 WWTP), as were the corresponding antibiotic resistance genes (ARGs). Strong correlations were observed between the daily loads of ABs and ARGs versus the size of the population served by each WWTP, as well as between AB and ARG loads at a single site. The efficiency of ABs and ARGs removal by the WWTPs varied according to site (and treatment process utilized) and target, although strong correlations were maintained between the population size served by WWTPs and daily loads of discharged ABs and ARGs into the environment. We therefore conclude that population size is the main determinant of the magnitude of AB and ARG burden in the environment.
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ArticleNumber | 117533 |
Author | Barden, Ruth Feil, Edward J Gaze, William H Snape, Jason Elder, Felicity C.T. Proctor, Kathryn Kasprzyk-Hordern, Barbara |
Author_xml | – sequence: 1 givenname: Felicity C.T. surname: Elder fullname: Elder, Felicity C.T. organization: Department of Chemistry, University of Bath, Bath BA2 7AY, UK – sequence: 2 givenname: Kathryn surname: Proctor fullname: Proctor, Kathryn organization: Department of Chemistry, University of Bath, Bath BA2 7AY, UK – sequence: 3 givenname: Ruth surname: Barden fullname: Barden, Ruth organization: Wessex Water, Bath BA2 7WW, UK – sequence: 4 givenname: William H orcidid: 0000-0002-9345-6204 surname: Gaze fullname: Gaze, William H organization: European Centre for Environment and Human Health, University of Exeter Medical School, University of Exeter ESI, Penryn Campus, Penryn TR10 9FE, UK – sequence: 5 givenname: Jason surname: Snape fullname: Snape, Jason organization: AstraZeneca Global Sustainability, Mereside, Macclesfield SK10 4TG, UK – sequence: 6 givenname: Edward J surname: Feil fullname: Feil, Edward J organization: The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK – sequence: 7 givenname: Barbara orcidid: 0000-0002-6809-2875 surname: Kasprzyk-Hordern fullname: Kasprzyk-Hordern, Barbara email: b.kasprzyk-hordern@bath.ac.uk organization: Department of Chemistry, University of Bath, Bath BA2 7AY, UK |
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Title | Spatiotemporal profiling of antibiotics and resistance genes in a river catchment: Human population as the main driver of antibiotic and antibiotic resistance gene presence in the environment |
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