What Inhibits Natural Killers’ Performance in Tumour

• Published in: International journal of molecular sciences Vol. 23; no. 13; p. 7030
• Main Authors: Papak, Ines, Chruściel, Elżbieta, Dziubek, Katarzyna, Kurkowiak, Małgorzata, Urban-Wójciuk, Zuzanna, Marjański, Tomasz, Rzyman, Witold, Marek-Trzonkowska, Natalia
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 24.06.2022; MDPI
• Subjects: activation receptors; Antigen presentation; Clinical trials; Cytokines; Cytotoxicity; Immune system; Immunoglobulins; immunosuppression; Immunotherapy; Infections; inhibitory receptors; Ligands; Lymphocytes; Lymphocytes T; Natural killer cells; natural killer cells (NK); Peptides; Population; Review; Severe acute respiratory syndrome coronavirus 2; Stem cells; T cell receptors; Tumors; tumour microenvironment (TME); Viral infections

Natural killer cells are innate lymphocytes with the ability to lyse tumour cells depending on the balance of their activating and inhibiting receptors. Growing numbers of clinical trials show promising results of NK cell-based immunotherapies. Unlike T cells, NK cells can lyse tumour cells independ...