What Inhibits Natural Killers’ Performance in Tumour

Natural killer cells are innate lymphocytes with the ability to lyse tumour cells depending on the balance of their activating and inhibiting receptors. Growing numbers of clinical trials show promising results of NK cell-based immunotherapies. Unlike T cells, NK cells can lyse tumour cells independ...

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Published inInternational journal of molecular sciences Vol. 23; no. 13; p. 7030
Main Authors Papak, Ines, Chruściel, Elżbieta, Dziubek, Katarzyna, Kurkowiak, Małgorzata, Urban-Wójciuk, Zuzanna, Marjański, Tomasz, Rzyman, Witold, Marek-Trzonkowska, Natalia
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 24.06.2022
MDPI
Subjects
activation receptors
Antigen presentation
Clinical trials
Cytokines
Cytotoxicity
Immune system
Immunoglobulins
immunosuppression
Immunotherapy
Infections
inhibitory receptors
Ligands
Lymphocytes
Lymphocytes T
Natural killer cells
natural killer cells (NK)
Peptides
Population
Review
Severe acute respiratory syndrome coronavirus 2
Stem cells
T cell receptors
Tumors
tumour microenvironment (TME)
Viral infections
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Abstract Natural killer cells are innate lymphocytes with the ability to lyse tumour cells depending on the balance of their activating and inhibiting receptors. Growing numbers of clinical trials show promising results of NK cell-based immunotherapies. Unlike T cells, NK cells can lyse tumour cells independent of antigen presentation, based simply on their activation and inhibition receptors. Various strategies to improve NK cell-based therapies are being developed, all with one goal: to shift the balance to activation. In this review, we discuss the current understanding of ways NK cells can lyse tumour cells and all the inhibitory signals stopping their cytotoxic potential.
AbstractList Natural killer cells are innate lymphocytes with the ability to lyse tumour cells depending on the balance of their activating and inhibiting receptors. Growing numbers of clinical trials show promising results of NK cell-based immunotherapies. Unlike T cells, NK cells can lyse tumour cells independent of antigen presentation, based simply on their activation and inhibition receptors. Various strategies to improve NK cell-based therapies are being developed, all with one goal: to shift the balance to activation. In this review, we discuss the current understanding of ways NK cells can lyse tumour cells and all the inhibitory signals stopping their cytotoxic potential.
Author Papak, Ines
Chruściel, Elżbieta
Kurkowiak, Małgorzata
Marek-Trzonkowska, Natalia
Urban-Wójciuk, Zuzanna
Dziubek, Katarzyna
Marjański, Tomasz
Rzyman, Witold
AuthorAffiliation 3 Laboratory of Immunoregulation and Cellular Therapies, Department of Family Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland
2 Department of Thoracic Surgery, Medical University of Gdansk, 80-210 Gdansk, Poland; tomasz.marjanski@gumed.edu.pl (T.M.); wrzyman@gumed.edu.pl (W.R.)
1 International Centre for Cancer Vaccine Science, University of Gdansk, Ul. Kładki 24, 80-822 Gdansk, Poland; ines.papak@phdstud.ug.edu.pl (I.P.); elzbieta.chrusciel@ug.edu.pl (E.C.); katarzyna.dziubek@phdstud.ug.edu.pl (K.D.); malgorzata.kurkowiak@ug.edu.pl (M.K.); zuzanna.urban-wojciuk@ug.edu.pl (Z.U.-W.)
AuthorAffiliation_xml – name: 2 Department of Thoracic Surgery, Medical University of Gdansk, 80-210 Gdansk, Poland; tomasz.marjanski@gumed.edu.pl (T.M.); wrzyman@gumed.edu.pl (W.R.)
– name: 1 International Centre for Cancer Vaccine Science, University of Gdansk, Ul. Kładki 24, 80-822 Gdansk, Poland; ines.papak@phdstud.ug.edu.pl (I.P.); elzbieta.chrusciel@ug.edu.pl (E.C.); katarzyna.dziubek@phdstud.ug.edu.pl (K.D.); malgorzata.kurkowiak@ug.edu.pl (M.K.); zuzanna.urban-wojciuk@ug.edu.pl (Z.U.-W.)
– name: 3 Laboratory of Immunoregulation and Cellular Therapies, Department of Family Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland
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CitedBy_id crossref_primary_10_3389_fonc_2022_1062765
crossref_primary_10_3390_ph16040537
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Snippet Natural killer cells are innate lymphocytes with the ability to lyse tumour cells depending on the balance of their activating and inhibiting receptors....
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SubjectTerms activation receptors
Antigen presentation
Clinical trials
Cytokines
Cytotoxicity
Immune system
Immunoglobulins
immunosuppression
Immunotherapy
Infections
inhibitory receptors
Ligands
Lymphocytes
Lymphocytes T
Natural killer cells
natural killer cells (NK)
Peptides
Population
Review
Severe acute respiratory syndrome coronavirus 2
Stem cells
T cell receptors
Tumors
tumour microenvironment (TME)
Viral infections
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Title What Inhibits Natural Killers’ Performance in Tumour
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https://pubmed.ncbi.nlm.nih.gov/PMC9266640
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Volume 23
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