What Inhibits Natural Killers’ Performance in Tumour

Natural killer cells are innate lymphocytes with the ability to lyse tumour cells depending on the balance of their activating and inhibiting receptors. Growing numbers of clinical trials show promising results of NK cell-based immunotherapies. Unlike T cells, NK cells can lyse tumour cells independ...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 23; no. 13; p. 7030
Main Authors Papak, Ines, Chruściel, Elżbieta, Dziubek, Katarzyna, Kurkowiak, Małgorzata, Urban-Wójciuk, Zuzanna, Marjański, Tomasz, Rzyman, Witold, Marek-Trzonkowska, Natalia
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 24.06.2022
MDPI
Subjects
activation receptors
Antigen presentation
Clinical trials
Cytokines
Cytotoxicity
Immune system
Immunoglobulins
immunosuppression
Immunotherapy
Infections
inhibitory receptors
Ligands
Lymphocytes
Lymphocytes T
Natural killer cells
natural killer cells (NK)
Peptides
Population
Review
Severe acute respiratory syndrome coronavirus 2
Stem cells
T cell receptors
Tumors
tumour microenvironment (TME)
Viral infections
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Summary:Natural killer cells are innate lymphocytes with the ability to lyse tumour cells depending on the balance of their activating and inhibiting receptors. Growing numbers of clinical trials show promising results of NK cell-based immunotherapies. Unlike T cells, NK cells can lyse tumour cells independent of antigen presentation, based simply on their activation and inhibition receptors. Various strategies to improve NK cell-based therapies are being developed, all with one goal: to shift the balance to activation. In this review, we discuss the current understanding of ways NK cells can lyse tumour cells and all the inhibitory signals stopping their cytotoxic potential.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23137030