Development of swelling/floating gastroretentive drug delivery system based on a combination of hydroxyethyl cellulose and sodium carboxymethyl cellulose for Losartan and its clinical relevance in healthy volunteers with CYP2C9 polymorphism - Chen, Ray-Neng; Ho, Hsiu-O; Yu, Chiao-Ya; Sheu, Ming-Thau (European journal of pharmaceutical sciences, 2010)
Keywords: Angiotensin II Type 1 Receptor Blockers - administration & dosage; Angiotensin II Type 1 Receptor Blockers - pharmacokinetics; Aryl Hydrocarbon Hydroxylases - genetics; Biological and medical sciences; Carboxymethylcellulose Sodium - chemistry; Cellulose - analogs & derivatives; Cellulose - chemistry; Chemistry, Pharmaceutical; Cytochrome P-450 CYP2C9; Drug Compounding - methods; Drug Delivery Systems - methods; Gastroretentive drug delivery systems; General pharmacology; Humans; Hydroxyethyl cellulose; Losartan; Losartan - administration & dosage; Losartan - pharmacokinetics; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polymorphism, Genetic; Polymorphisms; Sodium Bicarbonate - chemistry; Sodium carboxymethyl cellulose; Solubility; Tablets - administration & dosage; Tablets - chemistry; Hydroxyethyl cellulose; Gastroretentive drug delivery systems; Sodium carboxymethyl cellulose; Polymorphisms; Losartan; Imidazole derivatives; Tetrazole derivatives; Isozyme; Peptide hormone; Non peptide compound; Drug carrier; Octapeptide; Angiotensin II; Cellulose(hydroxyethyl); Human; Cellulose(carboxymethyl); Pharmaceutical technology; Swelling; Healthy subject; Enzyme; Cytochrome P450; Biphenyl derivatives; Antihypertensive agent; Sartan derivatives; Angiotensin antagonist; Floating system; Polymorphism