Capillary changes in hippocampal CA1 and CA3 areas of the aging rhesus monkey

• Published in: Acta neuropathologica Vol. 100; no. 6; pp. 665 - 672
• Main Authors: Keuker, J. I. H., Luiten, P. G. M., Fuchs, E.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.12.2000; Springer Nature B.V
• Subjects: Aging; Aging - pathology; Animal models; Animals; Astrocytes - pathology; Astrocytes - ultrastructure; Basement Membrane - metabolism; Basement Membrane - pathology; Basement Membrane - ultrastructure; Biological and medical sciences; Capillaries; Capillaries - pathology; Capillaries - physiopathology; Capillaries - ultrastructure; Cognition Disorders - etiology; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Cognitive ability; Collagen; Collagen - ultrastructure; Development. Metamorphosis. Moult. Ageing; Disease Models, Animal; Electron microscopy; Endothelium, Vascular - pathology; Endothelium, Vascular - physiopathology; Endothelium, Vascular - ultrastructure; Fibrils; Fundamental and applied biological sciences. Psychology; Hippocampus; Hippocampus - blood supply; Hippocampus - pathology; Hippocampus - physiopathology; Macaca mulatta; Male; Microvasculature; Monkeys & apes; Neural Pathways - pathology; Neural Pathways - physiopathology; Neuropil; Primates; Ultrastructure; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Animal model; Ageing; Monkey; Exploration; Electron microscopy; Pathology; Microcirculation; Vertebrata; Mammalia; Animal; Primates; Hippocampus; Brain (vertebrata)

The rhesus monkey is considered a useful animal model for studying human aging, because non-human primates show many of the neurobiological alterations that have been reported in aging humans. Cognitive impairment that accompanies normal aging may, at least partially, originate from capillary change...