Rs7853346 Polymorphism in lncRNA-PTENP1 and rs1799864 Polymorphism in CCR2 are Associated with Radiotherapy-Induced Cognitive Impairment in Subjects with Glioma Via Regulating PTENP1/miR-19b/CCR2 Signaling Pathway

• Published in: Biochemical genetics Vol. 60; no. 4; pp. 1159 - 1176
• Main Authors: Yang, Sen, Fu, Zhan-zhao, Zhang, Yan-qiu, Fu, Bao-hong, Dong, Li-xin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2022; Springer Nature B.V
• Subjects: 3' Untranslated regions; alleles; Biochemistry; Biomedical and Life Sciences; Biomedicine; bladder; CCR1 protein; CCR1 receptor; CCR2 protein; Cell proliferation; Cognitive ability; cognitive disorders; Gene expression; Gene polymorphism; genotype; Genotype & phenotype; Genotypes; Glioma; Global health; health status; Human Genetics; Impairment; luciferase; Medical Microbiology; Monocyte chemoattractant protein 1; mRNA; Multiple myeloma; myeloma; Non-coding RNA; Original Article; Parameters; Patients; Polymorphism; Public health; quantitative polymerase chain reaction; Radiation therapy; radiotherapy; Sequence analysis; Signal transduction; Signaling; Stem cells; Western blotting; Zoology; SNP; Radiotherapy; PTENP1; Cognitive impairment; miR-19b; CCR2

LncRNA-PTENP1 was reported to promote multiple myeloma cancer stem cell proliferation, and the G allele of rs7853346 polymorphism in lncRNA-PTENP1 was demonstrated to enhance the effect of lncRNA-PTENP1. In this study, we aimed to study the potential effect of lncRNA-PTENP1 and CCR2 mRNA polymorphis...