The Bright and Dark Sides of Reactive Oxygen Species Generated by Copper–Peptide Complexes

Copper ions bind to biomolecules (e.g., peptides and proteins) playing an essential role in many biological and physiological pathways in the human body. The resulting complexes may contribute to the initiation of neurodegenerative diseases, cancer, and bacterial and viral diseases, or act as therap...

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Published inSeparations Vol. 9; no. 3; p. 73
Main Authors Komarnicka, Urszula K., Lesiów, Monika K., Witwicki, Maciej, Bieńko, Alina
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.03.2022
Subjects
Alzheimer's disease
Amino acids
Anticancer properties
Biomolecules
Cancer
Chemical damage
Coordination compounds
Copper
Copper compounds
Hydrogen peroxide
Ligands
Lipid peroxidation
Lipids
Macromolecules
neurodegenerative diseases
Oxidation
Oxidative stress
Oxygen
Parkinson's disease
peptide
Peptides
Physiology
Proteins
reactive oxygen species
Viral diseases
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Summary:Copper ions bind to biomolecules (e.g., peptides and proteins) playing an essential role in many biological and physiological pathways in the human body. The resulting complexes may contribute to the initiation of neurodegenerative diseases, cancer, and bacterial and viral diseases, or act as therapeutics. Some compounds can chemically damage biological macromolecules and initiate the development of pathogenic states. Conversely, a number of these compounds may have antibacterial, antiviral, and even anticancer properties. One of the most significant current discussions in Cu biochemistry relates to the mechanisms of the positive and negative actions of Cu ions based on the generation of reactive oxygen species, including radicals that can interact with DNA molecules. This review aims to analyze various peptide–copper complexes and the mechanism of their action.
ISSN:2297-8739
2297-8739
DOI:10.3390/separations9030073