Evaluation of 3-carbamoylpropanoic acid analogs as inhibitors of human hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes

There is current interest in developing human hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) inhibitors for the treatment of anemia and other hypoxia-related diseases. We describe the synthesis of 3-carbamoylpropanoic acid derivatives and their evaluation as human PHD-2 inhibitors. M...

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Published inMedicinal chemistry research Vol. 30; no. 4; pp. 977 - 986
Main Authors Chong, MuiPhin, Toh, LeeRoy, Tumber, Anthony, Chan, YanYing, Chan, MunChiang, Abboud, Martine I., Schofield, Christopher J., Yeoh, KarKheng
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2021
Springer Nature B.V
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