Biochemical Differentiation of Gestational Compartments in the Midgestational Fetal Rabbit
Objectives: The fetal rabbit at midgestation is increasingly being used as a model in fetal diagnosis and therapy. In this study, we aimed to establish a reliable method for identification of the origin of sampled extra-embryonic fluids based on selected biochemical components. Methods: In 6 pregnan...
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Published in | Fetal diagnosis and therapy Vol. 16; no. 5; pp. 289 - 293 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Basel, Switzerland
Karger
01.09.2001
S. Karger AG |
Subjects | |
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Abstract | Objectives: The fetal rabbit at midgestation is increasingly being used as a model in fetal diagnosis and therapy. In this study, we aimed to establish a reliable method for identification of the origin of sampled extra-embryonic fluids based on selected biochemical components. Methods: In 6 pregnant does at 22 days of gestation, 18 gestational sacs were sampled for amniotic, allantoic and exocoelomic fluid. These fluids, as well as matching maternal and fetal blood samples, were assayed for levels of sodium, potassium, chloride, bicarbonate, total protein, alkaline phosphatase, γ-glutamyl transferase and progesterone. Results: Levels of sodium and potassium were, respectively, lower and higher in the allantoic fluid when compared to other extra-embryonic spaces. Amniotic fluid had a significantly lower total protein content and higher level of alkaline phosphatase when compared to the exocoelomic fluid. Significant levels of progesterone could only be detected in maternal blood. Conclusions: In the midgestational rabbit, a combined assay of potassium, alkaline phosphatase and progesterone can determine the gestational cavity of origin of the sampled fluid. The obtained gradients for these markers suggest compartment-specific production and/or inter-cavity transfer mechanisms. |
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AbstractList | <Objectives:< The fetal rabbit at midgestation is increasingly being used as a model in fetal diagnosis and therapy. In this study, we aimed to establish a reliable method for identification of the origin of sampled extra-embryonic fluids based on selected biochemical components. <Methods:< In 6 pregnant does at 22 days of gestation, 18 gestational sacs were sampled for amniotic, allantoic and exocoelomic fluid. These fluids, as well as matching maternal and fetal blood samples, were assayed for levels of sodium, potassium, chloride, bicarbonate, total protein, alkaline phosphatase, [gamma]-glutamyl transferase and progesterone. <Results:< Levels of sodium and potassium were, respectively, lower and higher in the allantoic fluid when compared to other extra-embryonic spaces. Amniotic fluid had a significantly lower total protein content and higher level of alkaline phosphatase when compared to the exocoelomic fluid. Significant levels of progesterone could only be detected in maternal blood. <Conclusions:< In the midgestational rabbit, a combined assay of potassium, alkaline phosphatase and progesterone can determine the gestational cavity of origin of the sampled fluid. The obtained gradients for these markers suggest compartment-specific production and/or inter-cavity transfer mechanisms. Copyright © 2001 S. Karger AG, Basel Objectives: The fetal rabbit at midgestation is increasingly being used as a model in fetal diagnosis and therapy. In this study, we aimed to establish a reliable method for identification of the origin of sampled extra-embryonic fluids based on selected biochemical components. Methods: In 6 pregnant does at 22 days of gestation, 18 gestational sacs were sampled for amniotic, allantoic and exocoelomic fluid. These fluids, as well as matching maternal and fetal blood samples, were assayed for levels of sodium, potassium, chloride, bicarbonate, total protein, alkaline phosphatase, γ-glutamyl transferase and progesterone. Results: Levels of sodium and potassium were, respectively, lower and higher in the allantoic fluid when compared to other extra-embryonic spaces. Amniotic fluid had a significantly lower total protein content and higher level of alkaline phosphatase when compared to the exocoelomic fluid. Significant levels of progesterone could only be detected in maternal blood. Conclusions: In the midgestational rabbit, a combined assay of potassium, alkaline phosphatase and progesterone can determine the gestational cavity of origin of the sampled fluid. The obtained gradients for these markers suggest compartment-specific production and/or inter-cavity transfer mechanisms. The fetal rabbit at midgestation is increasingly being used as a model in fetal diagnosis and therapy. In this study, we aimed to establish a reliable method for identification of the origin of sampled extra-embryonic fluids based on selected biochemical components. In 6 pregnant does at 22 days of gestation, 18 gestational sacs were sampled for amniotic, allantoic and exocoelomic fluid. These fluids, as well as matching maternal and fetal blood samples, were assayed for levels of sodium, potassium, chloride, bicarbonate, total protein, alkaline phosphatase, gamma-glutamyl transferase and progesterone. Levels of sodium and potassium were, respectively, lower and higher in the allantoic fluid when compared to other extra-embryonic spaces. Amniotic fluid had a significantly lower total protein content and higher level of alkaline phosphatase when compared to the exocoelomic fluid. Significant levels of progesterone could only be detected in maternal blood. In the midgestational rabbit, a combined assay of potassium, alkaline phosphatase and progesterone can determine the gestational cavity of origin of the sampled fluid. The obtained gradients for these markers suggest compartment-specific production and/or inter-cavity transfer mechanisms. OBJECTIVESThe fetal rabbit at midgestation is increasingly being used as a model in fetal diagnosis and therapy. In this study, we aimed to establish a reliable method for identification of the origin of sampled extra-embryonic fluids based on selected biochemical components.METHODSIn 6 pregnant does at 22 days of gestation, 18 gestational sacs were sampled for amniotic, allantoic and exocoelomic fluid. These fluids, as well as matching maternal and fetal blood samples, were assayed for levels of sodium, potassium, chloride, bicarbonate, total protein, alkaline phosphatase, gamma-glutamyl transferase and progesterone.RESULTSLevels of sodium and potassium were, respectively, lower and higher in the allantoic fluid when compared to other extra-embryonic spaces. Amniotic fluid had a significantly lower total protein content and higher level of alkaline phosphatase when compared to the exocoelomic fluid. Significant levels of progesterone could only be detected in maternal blood.CONCLUSIONSIn the midgestational rabbit, a combined assay of potassium, alkaline phosphatase and progesterone can determine the gestational cavity of origin of the sampled fluid. The obtained gradients for these markers suggest compartment-specific production and/or inter-cavity transfer mechanisms. |
Author | Devlieger, R. Deprest, J. Vereecken, A. Wu, J. Gratacós, E. Ardon, H. |
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Keywords | Fetal membranes Rabbit Amnion Coelocentesis Chorion Coelomic cavity Biochemical analysis Allantoic fluid Biochemistry Lagomorpha Experimental study Coelomic fluid Pregnancy Vertebrata Mammalia Animal Amniotic fluid Fetus |
Language | English |
License | Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. CC BY 4.0 Copyright 2001 S. Karger AG, Basel |
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References | Jauniaux E, Jurkovic D, Gulbis B, Gervy C, Ooms HA, Campbell S: Biochemical composition of exocoelomic fluid in early human pregnancy. Hum Reprod 1991;78:1124-1128. Setchell GB, Ploen L, Ritzen EM: Reduction in fluid secretion by rat testis by drugs that block potassium channels. J Reprod Fertil 1998;112:87-94.9538333 Mossman HW: Lagomorpha and rodentia; in Mossman HW (ed): Vertebrate fetal membranes. Houndsmill, MacMillan Press, 1987, p 216. Gratacós E, Yamamoto H, Papadopoulos NA, Adriaenssens T, Philips T, Lerut TE, Deprest JA: The midgestational rabbit as a model for the creation of membrane defects following needle-fetoscopy. Am J Obstet Gynecol 1999;180:1263-1267.10329887 Jauniaux E, Lees C, Jurkovic D, Campbell S, Gulbis B: Transfer of inulin across the first trimester human placenta. Am J Obstet Gynecol 1997;176:33-36.9024085 Gulbis B, Jauniaux E, Jurkovic D, Thiry P, Campbell S, Ooms HA: Determination of protein pattern in embryonic cavities of human pregnancy: A means to understand materno-embryonic exchanges. Hum Reprod 1992;7:886-889.1380005 Jurkovic D, Jauniaux E, Campbell S, Pandya P, Cardy DL, Nikolaides KH: Coelocentesis, a new technique for early prenatal diagnosis. Lancet 1993;341:1623-1624.809999310.1016/0140-6736(93)90761-5 Santoyala-Forgas J, Duval J, Prespin C, Vengalil S, Kushwaha A, Fortman J: Extracoelomic fluid osmometry and electrolyte composition during early pregnancy in the baboon. Am J Obstet Gynecol 1998;179:1124-1127.9822486 Jauniaux E, Gulbis B, Jurkovic D, Schaaps JP, Campbell S, Meuris S: Protein and steroid levels in embryonic cavities in early human pregnancy. Hum Reprod 1993;5:782-787. Beaudoin S, Simon L, Simeoni J, Sacquin P, Bargy F: Surgical approach of an early mammalian embryo: The rabbit model. Fet Diagn Ther 1998;13:82-85.965065210.1159/000020811 Campbell J, Wathen N, Perry G, Soneji S, Sourial N, Chard T: The coelomic cavity: An important site of materno-fetal nutritient exchange in the first trimester of pregnancy. Br J Obstet Gynecol 1995;100:767-776. Moscoso G: On flux in extraembryonic fluids. Ultrasound Obstet Gynecol 1999;13:389-391(opinion). Jauniaux E, Gulbis B, Hyett J, Nikolaides KH: Biochemical analysis of mesenchymal fluids in early pregnancy. Am J Obstet Gynecol 1998;178:765-769.9579441 Jurkovic D, Jauniaux E, Campbell S, Mitchell M, Lees C, Layton M: Detection of sickle gene by coelocentesis in early pregnancy: A new approach to prenatal diagnosis of single gene disorders. Hum Reprod 1995;5:1287-1289. Gratacós E, Wu J, Yesildaglar N, Devlieger R, Pijnenborg R, Deprest JA: Successful sealing of fetoscopic access sites with collagen plugs in the rabbit model. Am J Obstet Gynecol 2000;182:142-146.10649169 Wang G, Williamson R, Mueller G: Ultrasound-guided gene transfer to hepatocytes in utero. Fetal Diagn Ther 1998;1:197-205.10.1159/000020838 Waddel WJ: A simple ultraviolet spectrophotometric method for the determination of protein. J Lab Clin Med 1956;48:311. Baumgartner TL, Baumgartner BJ, Hudon L, Moise KJ: Ultrasonographically guided direct gene transfer in utero: Successful induction of beta-galactosidase in a rabbit model. Am J Obstet Gynecol 1999;181:848-852.10521740 ref3 ref2 ref1 |
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Snippet | Objectives: The fetal rabbit at midgestation is increasingly being used as a model in fetal diagnosis and therapy. In this study, we aimed to establish a... The fetal rabbit at midgestation is increasingly being used as a model in fetal diagnosis and therapy. In this study, we aimed to establish a reliable method... <Objectives:< The fetal rabbit at midgestation is increasingly being used as a model in fetal diagnosis and therapy. In this study, we aimed to establish a... OBJECTIVESThe fetal rabbit at midgestation is increasingly being used as a model in fetal diagnosis and therapy. In this study, we aimed to establish a... |
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SubjectTerms | Alkaline Phosphatase - analysis Allantois - metabolism Amniotic Fluid - chemistry Analysis of complex biological substances Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Blood and biological fluids Body Fluids - chemistry Extraembryonic Membranes - metabolism Female Fetal Blood - chemistry Fundamental and applied biological sciences. Psychology gamma-Glutamyltransferase - analysis Gestational Age Potassium - analysis Pregnancy Progesterone - analysis Proteins - analysis Rabbits Sodium - analysis |
Title | Biochemical Differentiation of Gestational Compartments in the Midgestational Fetal Rabbit |
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