Modeling the precision and robustness of Hunchback border during Drosophila embryonic development

• Published in: Journal of theoretical biology Vol. 254; no. 2; pp. 390 - 399
• Main Authors: Hardway, Heather, Mukhopadhyay, Bibhash, Burke, Timothy, James Hitchman, Theron, Forman, Robin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 21.09.2008
• Subjects: Animals; Bicoid; Body Patterning - genetics; Computer Simulation; DNA-Binding Proteins - genetics; Drosophila; Drosophila - embryology; Drosophila Proteins - genetics; Embryo, Nonmammalian - physiology; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Genetic regulatory network; Homeodomain Proteins - genetics; Hunchback; Mathematical modeling; Morphogenesis - genetics; Robust; Trans-Activators - genetics; Transcription Factors - genetics; Hunchback; Bicoid; Mathematical modeling; Genetic regulatory network; Robust

During anterior–posterior axis specification in the Drosophila embryo, the Hunchback (Hb) protein forms a sharp boundary at the mid-point of the embryo with great positional precision. While Bicoid (Bcd) is a known upstream regulator for hb expression, there is evidence to suggest that Hb effectivel...