Effects of temperature on heat pain adaptation and habituation in men and women

• Published in: Pain (Amsterdam) Vol. 151; no. 3; pp. 737 - 743
• Main Authors: Hashmi, Javeria A., Davis, Karen D.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier B.V 01.12.2010; Elsevier
• Subjects: Adaptation; Adaptation, Physiological - physiology; Adult; Area Under Curve; Biological and medical sciences; Female; Fundamental and applied biological sciences. Psychology; Habituation; Habituation, Psychophysiologic - physiology; Heat pain; Hot Temperature; Humans; Illness and personality; Illness, stress and coping; Male; Pain - physiopathology; Pain Measurement; Pain Threshold - physiology; Psychology and medicine; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychophysics; Sex Characteristics; Sex differences; Sex Factors; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Temperature; Temporal summation; Vertebrates: nervous system and sense organs; Temporal summation; Temperature; Sex differences; Psychophysics; Heat pain; Adaptation; Habituation; Human; Pain; Sex; Temperature effect
• ISSN: 0304-3959; 1872-6623
• DOI: 10.1016/j.pain.2010.08.046

We recently reported that women report greater pain adaptation and habituation to moderately painful heat stimuli than men (Hashmi and Davis [16]); but slightly lower temperatures were needed to evoke moderate pain in the women. Hardy et al (1962) and LaMotte (1979) suggested that pain adaptation is most prominent at modest noxious heat temperatures and may occur at temperatures close to pain thresholds. Thus, as a follow-up to our previous study, we examined the role of absolute temperature in pain adaptation and habituation in men and women and assessed whether pain threshold impacts these findings. We hypothesised that pain adaptation and habituation would be more prominent at low and moderate temperatures, and that higher temperatures would induce pain adaptation and habituation in women but not in men. We further hypothesized that pain adaptation would not be correlated with pain thresholds. To test this, we obtained continuous ratings of pain evoked by 44.5–47.5°C stimuli applied to the dorsal foot of men and women. Each run consisted of three 30s stimuli at the same temperature with a 60s inter-stimulus interval. Women showed within-stimulus adaptation of total pain at all temperatures, but men showed significant adaptation to temperatures less than 47°C. There were no sex differences in inter-stimulus habituation and both men and women reported habituation to temperatures less than 46°C. Pain thresholds did not correlate with pain adaptation. These data highlight the temperature-sensitivity and sex differences of pain adaptation and habituation.