Paradigm change in urological, gynaecological and breast cancer management: A new practice-changing data from ASCO 2022 annual meeting

• Published in: Cancer treatment and research communications Vol. 35; p. 100677
• Main Authors: Andrif, Meriem, Elmarrachi, Hafsa, Ismaili, Nabil
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 2023; Elsevier
• Subjects: ASCO 2022; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Chemotherapy; Drug discovery; Everolimus - therapeutic use; Female; Gynecological cancer; Hormonotherapy; Humans; Immunotherapy; Medical Oncology; Surgery; Urogynecology; Urological cancer; Urological cancer; Chemotherapy; Immunotherapy; Hormonotherapy; Surgery; Breast cancer; Gynecological cancer; Drug discovery; Urogynecology; ASCO 2022
• ISSN: 2468-2942; 2468-2942
• DOI: 10.1016/j.ctarc.2022.100677

•EVEREST S0931: Everolimus improved recurrence-free survival in the adjuvant situation in high-risk renal carcinoma.•ARASENS: This trial demonstrated the benefit of adding darolutamide to ADT plus docetaxel in improving the OS for the early treatment of mHSPC.•ATHENA-MONO: In newly diagnosed advanced ovarian cancer treated with platinum-based therapy, progression-free survival was improved by the rucaparib maintenance, also demonstrated in the positive HRD population.•DESTINY-BREAST04: Further investigating the need to redefine the HER2 population with HER2 low metastatic breast cancer, where trastuzumab deruxtecan demonstrated a survival benefit. Changing medical practice has been a constant process based on many scientific findings for years. In the oncology community, the American Society of Clinical Oncology (ASCO), one of the major annual conferences, presented the latest updates on practice-changing in cancer. At the recent meeting of 2022, held this year on June 2–6, researchers presented essential findings in urological, gynecological, and breast cancer management. In urological cancer, olaparib + abiraterone was demonstrated thru the PROpel trial to benefit in first-line treatment mCRPC regardless of the HRR stratification factor, along with the adjuvant therapy everolimus, for fully resected RCC in the EVEREST trial. In gynecological cancer, tisotumab vedotin demonstrated a potential role in improving clinical outcomes in 1st line r/mCC thru InnovaTV-205. In breast cancer, trastuzumab deruxtecan showed significant benefit for redefined human epidermal growth factors receptor 2 status in HER2 low BC patients, where current targeted-HER2 therapies are ineffective in the DESTINY-BREAST 04 study. The use of Immuno-based combinations in the medical management of TNBC patients has been supported thru several recent studies, showing positive results and outcomes, as demonstrated by the expert's opinions in Rizzo et al. research papers. In this article, we resumed the different renowned and what we considered intriguing to review studies presented during these three long sessions at the ASCO 2022 meeting.