Recruitment of TNF ligands to lipid rafts is mediated by their physical association with caveolin‐1

• Published in: FEBS letters Vol. 596; no. 2; pp. 211 - 218
• Main Authors: Glukhova, Xenia A., Trizna, Julia A., Melnik, Bogdan S., Proussakova, Olga V., Beletsky, Igor P.
• Format: Journal Article
• Language: English
• Published: England 01.01.2022
• Subjects: Caveolin 1 - genetics; Caveolin 1 - metabolism; caveolin‐1; CD40 Ligand - genetics; CD40 Ligand - metabolism; CD40L; HeLa Cells; Humans; Ligands; lipid rafts; Membrane Microdomains - metabolism; physical association; Protein Binding; Protein Transport; TNF; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; CD40L; caveolin-1; lipid rafts; physical association; TNF

Activities of the tumour necrosis factor (TNF) family members are associated with their targeting to lipid rafts, specialised regions of the plasma membrane. Herein, we investigated the physical association of TNF and its family members cluster of differentiation 40 ligand (CD40L) and tumour necrosi...