Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-κB pathway

• Published in: Critical care medicine Vol. 39; no. 2; p. 328
• Main Authors: Kwon, Woon Yong, Suh, Gil Joon, Kim, Kyung Su, Kwak, Young Ho
• Format: Journal Article
• Language: English
• Published: United States 01.02.2011
• Subjects: Animals; Biopsy, Needle; Disease Models, Animal; Down-Regulation; Endotoxemia - drug therapy; Endotoxemia - genetics; Endotoxemia - mortality; Follow-Up Studies; Gene Expression Regulation - drug effects; Immunohistochemistry; Male; NF-kappa B - drug effects; NF-kappa B - genetics; Niacin - administration & dosage; Pneumonia - drug therapy; Pneumonia - genetics; Pneumonia - mortality; Pneumonia - pathology; Pulse Therapy, Drug; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction; Survival Rate; Time Factors

To examine whether niacin attenuates lung inflammation and improves survival during sepsis and to determine whether the beneficial effects of niacin are associated with downregulation of the nuclear factor (NF)-κB pathway. Prospective laboratory study. University laboratory. Male Sprague-Dawley rats...