Sustained and focused hepatitis B virus nucleocapsid–specific T‐cell immunity in liver transplant recipients compared to individuals with chronic and self‐limited hepatitis B virus infection
Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft‐ and patient‐survival. Treatment with HBV‐specific immunoglobulins (HBIG) in combination with nucleos(t)ide analogs is effective in preventing HBV reinfection of the graft and improving OLT...
Saved in:
| Published in | Liver transplantation Vol. 14; no. 4; pp. 478 - 485 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.04.2008
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1527-6465 1527-6473 1527-6473 |
| DOI | 10.1002/lt.21384 |
Cover
Loading…
| Abstract | Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft‐ and patient‐survival. Treatment with HBV‐specific immunoglobulins (HBIG) in combination with nucleos(t)ide analogs is effective in preventing HBV reinfection of the graft and improving OLT outcome. However, the role of HBV‐specific cellular immunity in viral containment in immune suppressed patients in general and in OLT recipients in particular is unclear. To test whether or not OLT recipients maintain robust HBV‐specific cellular immunity, the cellular immune response against HBV was assessed in 15 OLT recipients and 27 individuals with chronic and 24 subjects with self‐limited HBV infection, respectively; using an overlapping peptide set spanning the viral nucleocapsid‐ and envelope‐protein sequences. The data demonstrate that OLT recipients mounted fewer but stronger clusters of differentiation (CD)8 T cell responses than subjects with self‐limited HBV infection and showed a preferential targeting of the nucleocapsid antigen. This focused response pattern was similar to responses seen in chronically infected subjects with undetectable viremia, but significantly different from patients who presented with elevated HBV viremia and who mounted mainly immune responses against the envelope protein. In conclusion, virus‐specific CD4 T cell–mediated responses were only detected in subjects with self‐limited HBV infection. Thus, the profile of the cellular immunity against HBV was in immune suppressed patients similar to subjects with chronic HBV infection with suppressed HBV‐DNA. Liver Transpl 2008. © 2008 AASLD. |
|---|---|
| AbstractList | Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft- and patient-survival. Treatment with HBV-specific immunoglobulins (HBIG) in combination with nucleos(t)ide analogs is effective in preventing HBV reinfection of the graft and improving OLT outcome. However, the role of HBV-specific cellular immunity in viral containment in immune suppressed patients in general and in OLT recipients in particular is unclear. To test whether or not OLT recipients maintain robust HBV-specific cellular immunity, the cellular immune response against HBV was assessed in 15 OLT recipients and 27 individuals with chronic and 24 subjects with self-limited HBV infection, respectively; using an overlapping peptide set spanning the viral nucleocapsid- and envelope-protein sequences. The data demonstrate that OLT recipients mounted fewer but stronger clusters of differentiation (CD)8 T cell responses than subjects with self-limited HBV infection and showed a preferential targeting of the nucleocapsid antigen. This focused response pattern was similar to responses seen in chronically infected subjects with undetectable viremia, but significantly different from patients who presented with elevated HBV viremia and who mounted mainly immune responses against the envelope protein. In conclusion, virus-specific CD4 T cell-mediated responses were only detected in subjects with self-limited HBV infection. Thus, the profile of the cellular immunity against HBV was in immune suppressed patients similar to subjects with chronic HBV infection with suppressed HBV-DNA.Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft- and patient-survival. Treatment with HBV-specific immunoglobulins (HBIG) in combination with nucleos(t)ide analogs is effective in preventing HBV reinfection of the graft and improving OLT outcome. However, the role of HBV-specific cellular immunity in viral containment in immune suppressed patients in general and in OLT recipients in particular is unclear. To test whether or not OLT recipients maintain robust HBV-specific cellular immunity, the cellular immune response against HBV was assessed in 15 OLT recipients and 27 individuals with chronic and 24 subjects with self-limited HBV infection, respectively; using an overlapping peptide set spanning the viral nucleocapsid- and envelope-protein sequences. The data demonstrate that OLT recipients mounted fewer but stronger clusters of differentiation (CD)8 T cell responses than subjects with self-limited HBV infection and showed a preferential targeting of the nucleocapsid antigen. This focused response pattern was similar to responses seen in chronically infected subjects with undetectable viremia, but significantly different from patients who presented with elevated HBV viremia and who mounted mainly immune responses against the envelope protein. In conclusion, virus-specific CD4 T cell-mediated responses were only detected in subjects with self-limited HBV infection. Thus, the profile of the cellular immunity against HBV was in immune suppressed patients similar to subjects with chronic HBV infection with suppressed HBV-DNA. Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft- and patient-survival. Treatment with HBV-specific immunoglobulins (HBIG) in combination with nucleos(t)ide analogs is effective in preventing HBV reinfection of the graft and improving OLT outcome. However, the role of HBV-specific cellular immunity in viral containment in immune suppressed patients in general and in OLT recipients in particular is unclear. To test whether or not OLT recipients maintain robust HBV-specific cellular immunity, the cellular immune response against HBV was assessed in 15 OLT recipients and 27 individuals with chronic and 24 subjects with self-limited HBV infection, respectively; using an overlapping peptide set spanning the viral nucleocapsid- and envelope-protein sequences. The data demonstrate that OLT recipients mounted fewer but stronger clusters of differentiation (CD)8 T cell responses than subjects with self-limited HBV infection and showed a preferential targeting of the nucleocapsid antigen. This focused response pattern was similar to responses seen in chronically infected subjects with undetectable viremia, but significantly different from patients who presented with elevated HBV viremia and who mounted mainly immune responses against the envelope protein. In conclusion, virus-specific CD4 T cell-mediated responses were only detected in subjects with self-limited HBV infection. Thus, the profile of the cellular immunity against HBV was in immune suppressed patients similar to subjects with chronic HBV infection with suppressed HBV-DNA. Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft‐ and patient‐survival. Treatment with HBV‐specific immunoglobulins (HBIG) in combination with nucleos(t)ide analogs is effective in preventing HBV reinfection of the graft and improving OLT outcome. However, the role of HBV‐specific cellular immunity in viral containment in immune suppressed patients in general and in OLT recipients in particular is unclear. To test whether or not OLT recipients maintain robust HBV‐specific cellular immunity, the cellular immune response against HBV was assessed in 15 OLT recipients and 27 individuals with chronic and 24 subjects with self‐limited HBV infection, respectively; using an overlapping peptide set spanning the viral nucleocapsid‐ and envelope‐protein sequences. The data demonstrate that OLT recipients mounted fewer but stronger clusters of differentiation (CD)8 T cell responses than subjects with self‐limited HBV infection and showed a preferential targeting of the nucleocapsid antigen. This focused response pattern was similar to responses seen in chronically infected subjects with undetectable viremia, but significantly different from patients who presented with elevated HBV viremia and who mounted mainly immune responses against the envelope protein. In conclusion, virus‐specific CD4 T cell–mediated responses were only detected in subjects with self‐limited HBV infection. Thus, the profile of the cellular immunity against HBV was in immune suppressed patients similar to subjects with chronic HBV infection with suppressed HBV‐DNA. Liver Transpl 2008. © 2008 AASLD. Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft- and patient-survival. Treatment with HBV-specific immunoglobulins (HBIG) in combination with nucleos(t)ide analogs is effective in preventing HBV reinfection of the graft and improving OLT outcome. However, the role of HBV-specific cellular immunity in viral containment in immune suppressed patients in general and in OLT recipients in particular is unclear. To test whether or not OLT recipients maintain robust HBV-specific cellular immunity, the cellular immune response against HBV was assessed in 15 OLT recipients and 27 individuals with chronic and 24 subjects with self-limited HBV infection, respectively; using an overlapping peptide set spanning the viral nucleocapsid- and envelope-protein sequences. The data demonstrate that OLT recipients mounted fewer but stronger clusters of differentiation (CD)8 T cell responses than subjects with self-limited HBV infection and showed a preferential targeting of the nucleocapsid antigen. This focused response pattern was similar to responses seen in chronically infected subjects with undetectable viremia, but significantly different from patients who presented with elevated HBV viremia and who mounted mainly immune responses against the envelope protein. In conclusion, virus-specific CD4 T cell-mediated responses were only detected in subjects with self-limited HBV infection. Thus, the profile of the cellular immunity against HBV was in immune suppressed patients similar to subjects with chronic HBV infection with suppressed HBV-DNA. Liver Transpl 2008. |
| Author | Terrault, Norah A. Loggi, Elisabetta Biselli, Maurizio Bertoletti, Antonio Andreone, Pietro Chisholm, John V. Bihl, Florian Brander, Christian Morelli, Maria C. Cursaro, Carmela Bernardi, Mauro |
| Author_xml | – sequence: 1 givenname: Florian surname: Bihl fullname: Bihl, Florian – sequence: 2 givenname: Elisabetta surname: Loggi fullname: Loggi, Elisabetta – sequence: 3 givenname: John V. surname: Chisholm fullname: Chisholm, John V. – sequence: 4 givenname: Maurizio surname: Biselli fullname: Biselli, Maurizio – sequence: 5 givenname: Maria C. surname: Morelli fullname: Morelli, Maria C. – sequence: 6 givenname: Carmela surname: Cursaro fullname: Cursaro, Carmela – sequence: 7 givenname: Norah A. surname: Terrault fullname: Terrault, Norah A. – sequence: 8 givenname: Mauro surname: Bernardi fullname: Bernardi, Mauro – sequence: 9 givenname: Antonio surname: Bertoletti fullname: Bertoletti, Antonio – sequence: 10 givenname: Pietro surname: Andreone fullname: Andreone, Pietro email: andreone@med.unibo.it – sequence: 11 givenname: Christian surname: Brander fullname: Brander, Christian |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18324666$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUFu1DAUhi3UirYDEidAXkE3GRzbcZIlVBQqjcSCYR05tqN5yLGD7Uw1ux4BiStxkp4ED9MWCRW88bP0vc_P_s_QkfPOIPSiJMuSEPrGpiUtWcOfoNOyonUheM2OHmpRnaCzGL8SUpZVS56ik7JhlAshTtHPz3NMEpzRWDqNB6_mmOuNmWSCBBG_w1sIc8RuVtZ4JacI-vbmR5yMggEUXt_efFfGWgzjODtIOwwOW9iagFOQLk5WuoRDpicwLkWs_DjJkO9IPqMatqBnaSO-hrTBahO8y9b9LNHYIcstjJAeHQncYFQC756h4yErzPO7fYG-XL5fX3wsVp8-XF28XRWKNRUvGqEpZS3Vg-xrXRNGq6qmWkkqy4aLnvWC5UNNNK8U7wWlvJK54m1NOKGGLdDrg3cK_ttsYupGiPvHS2f8HLuWUMZaltcCvfovmYWCs6rJ4Ms7cO5Ho7spwCjDrrtPKAPnB0AFH2Mwwx-EdPvwO5u63-FndPkXqiDJ_QflJMA-1lAcGq7Bmt0_xd1qfeB_AUrIxeg |
| CitedBy_id | crossref_primary_10_1002_lt_21674 crossref_primary_10_1016_j_jhep_2008_08_026 crossref_primary_10_1002_lt_21729 crossref_primary_10_1007_s15010_012_0320_z crossref_primary_10_1097_QAD_0b013e328359b7ae crossref_primary_10_1111_jvh_12255 |
| Cites_doi | 10.1084/jem.176.1.157 10.1016/S0168-8278(01)00080-0 10.1182/blood.V77.1.195.195 10.1128/JVI.02509-06 10.1002/eji.200737365 10.1038/nm1520 10.1097/00002030-200404090-00004 10.1038/nm1096-1104 10.1128/JVI.02844-06 10.1172/JCI3731 10.1084/jem.181.6.1957 10.1128/JVI.78.11.5707-5719.2004 10.1053/jhep.2001.23045 10.1016/S0022-1759(02)00541-0 10.1084/jem.178.4.1459 10.1172/JCI116950 10.1097/QAD.0b013e328182df03 10.1086/432103 10.1172/JCI118592 10.1111/j.1399-0012.2006.00490.x 10.1186/1479-5876-3-20 10.1099/vir.0.81920-0 10.1038/281646a0 10.4049/jimmunol.173.9.5355 10.1084/jem.181.3.1047 10.7326/0003-4819-96-4-447 10.1016/j.transproceed.2005.10.017 10.1172/JCI118902 10.1089/088922204322996554 10.1038/nature05115 10.1002/lt.20258 10.1053/jhep.2003.50310 10.1099/0022-1317-83-6-1267 10.1002/lt.20492 10.1016/S0168-8278(03)00292-7 10.1097/00007890-200002270-00017 10.1084/jem.191.8.1269 10.1086/491741 10.1128/JVI.78.9.4463-4477.2004 10.1084/jem.20051775 10.4049/jimmunol.145.10.3442 |
| ContentType | Journal Article |
| Copyright | Copyright © 2008 American Association for the Study of Liver Diseases (c) 2008 AASLD. |
| Copyright_xml | – notice: Copyright © 2008 American Association for the Study of Liver Diseases – notice: (c) 2008 AASLD. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7T5 7U9 H94 |
| DOI | 10.1002/lt.21384 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Immunology Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AIDS and Cancer Research Abstracts Immunology Abstracts Virology and AIDS Abstracts |
| DatabaseTitleList | MEDLINE - Academic MEDLINE AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1527-6473 |
| EndPage | 485 |
| ExternalDocumentID | 18324666 10_1002_lt_21384 LT21384 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GrantInformation_xml | – fundername: Swiss National Science Foundation funderid: SNF‐PBSKB‐102686 – fundername: Associazione per la Ricerca sulle Malattie Epatiche (Bologna, Italy) |
| GroupedDBID | --- --K .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1B1 1L6 1OC 1~5 24P 31~ 33P 3SF 3WU 4.4 4G. 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5VS 7-5 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEDT AAESR AAEVG AAHHS AALRI AAOCO AAONW AAQFI AAQXK AASGY AAXRX AAXUO AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABLJU ABMAC ABPVW ABWVN ABXGK ACAHQ ACCFJ ACCZN ACGFO ACGFS ACLDA ACMXC ACPOU ACRPL ACSCC ACXBN ACXQS ADEOM ADIZJ ADKYN ADMGS ADMUD ADNMO ADOZA ADXAS ADZMN AECAP AEEZP AEGXH AEIMD AENEX AEQDE AEUQT AFBPY AFGKR AFPWT AFUWQ AFZJQ AHMBA AIACR AIURR AIWBW AJAOE AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AZBYB AZVAB BAFTC BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EBS EJD F00 F01 F04 F5P FD6 FDB FEDTE FGOYB FUBAC G-S G.N GNP GODZA H.X HBH HF~ HHY HHZ HVGLF HZ~ IHE IX1 J0M J5H JPC KBYEO KQQ LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M41 MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB NQ- O66 O9- OIG OK1 OVD P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 QRW R.K R2- RIG ROL RPZ RWI RX1 SEW SSZ SUPJJ TEORI UB1 UHS V2E V8K V9Y W8V W99 WBKPD WHWMO WIH WIJ WIK WIN WJL WOHZO WQJ WRC WVDHM WXI X7M XG1 XV2 ZZTAW ~IA ~WT AAFWJ AAYXX ACZKN AFNMH AGQPQ AHQVU CITATION MEWTI WXSBR AAMMB AEFGJ AGXDD AIDQK AIDYY CGR CUY CVF ECM EIF NPM 7X8 7T5 7U9 H94 |
| ID | FETCH-LOGICAL-c3854-86d22392dfab7d70325572dca2a1846b3b63ca270d45c4b62245a5c44970402e3 |
| IEDL.DBID | DR2 |
| ISSN | 1527-6465 1527-6473 |
| IngestDate | Thu Jul 10 18:06:25 EDT 2025 Fri Jul 11 09:59:27 EDT 2025 Mon Jul 21 05:44:17 EDT 2025 Tue Jul 01 05:14:47 EDT 2025 Thu Apr 24 23:06:15 EDT 2025 Wed Jan 22 16:26:33 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | (c) 2008 AASLD. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3854-86d22392dfab7d70325572dca2a1846b3b63ca270d45c4b62245a5c44970402e3 |
| Notes | These authors contributed equally to this study. Telephone: 39.051.6363618; FAX: 39.051.345806 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/lt.21384 |
| PMID | 18324666 |
| PQID | 70464358 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_902339333 proquest_miscellaneous_70464358 pubmed_primary_18324666 crossref_primary_10_1002_lt_21384 crossref_citationtrail_10_1002_lt_21384 wiley_primary_10_1002_lt_21384_LT21384 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | April 2008 2008-04-00 2008-Apr 20080401 |
| PublicationDateYYYYMMDD | 2008-04-01 |
| PublicationDate_xml | – month: 04 year: 2008 text: April 2008 |
| PublicationDecade | 2000 |
| PublicationPlace | Hoboken |
| PublicationPlace_xml | – name: Hoboken – name: United States |
| PublicationTitle | Liver transplantation |
| PublicationTitleAlternate | Liver Transpl |
| PublicationYear | 2008 |
| Publisher | Wiley Subscription Services, Inc., A Wiley Company |
| Publisher_xml | – name: Wiley Subscription Services, Inc., A Wiley Company |
| References | 2005; 192 2004; 20 2000; 69 1991; 77 1982; 96 2003; 38 2003; 39 2004 1990; 145 1996; 98 2007; 13 1996; 97 2003; 275 2000; 191 2007; 37 2004; 10 2006; 20 2000; 14 2004; 18 2002; 83 1992; 176 2006; 87 2004; 173 2004; 78 2007; 81 2005; 3 2005; 37 2001; 33 2001; 34 1979; 281 2007; 21 2006; 203 1996; 2 1998; 102 1994; 93 2005; 11 1993; 178 1995; 181 2006; 443 Boni (R16-13-20250326) 2001; 33 KiddLjunggren (R25-13-20250326) 2002; 83 Rehermann (R8-13-20250326) 1996; 97 Murray (R33-13-20250326) 1992; 176 Rehermann (R7-13-20250326) 1995; 181 Kaufmann (R26-13-20250326) 2004; 78 Kiepiela (R36-13-20250326) 2007; 13 Woodberry (R38-13-20250326) 2005; 192 Marzano (R5-13-20250326) 2001; 34 Watts (R40-13-20250326) 1993; 178 Day (R41-13-20250326) 2006; 443 Marinos (R42-13-20250326) 2000; 69 Bertoletti (R10-13-20250326) 2003; 38 Woodberry (R37-13-20250326) 2005; 192 Bertoletti (R35-13-20250326) 2006; 87 Maini (R11-13-20250326) 2000; 191 Murakami (R17-13-20250326) 2006; 20 Reed (R19-13-20250326) 1991; 77 Camci (R2-13-20250326) 2005; 37 Michalak (R34-13-20250326) 1994; 93 Boni (R14-13-20250326) 1998; 102 Hoofnagle (R18-13-20250326) 1982; 96 Norris (R27-13-20250326) 2004; 20 Simitsek (R39-13-20250326) 1995; 181 Frahm (R29-13-20250326) 2007; 37 Draenert (R23-13-20250326) 2003; 275 Webster (R12-13-20250326) 2004; 78 Roche (R4-13-20250326) 2004; 10 Bihl (R20-13-20250326) 2005; 3 Boni (R13-13-20250326) 2007; 81 Draenert (R28-13-20250326) 2004; 18 Rosen (R44-13-20250326) 2004; 173 Rehermann (R6-13-20250326) 1996; 2 Ferrari (R32-13-20250326) 1990; 145 Bihl (R31-13-20250326) 2007; 21 Klein (R43-13-20250326) 2006; 203 Boni (R15-13-20250326) 2003; 39 McGory (R3-13-20250326) 2000; 14 Terrault (R1-13-20250326) 2005; 11 Galibert (R24-13-20250326) 1979; 281 Penna (R9-13-20250326) 1996; 98 Bihl (R30-13-20250326) 2007; 81 |
| References_xml | – volume: 178 start-page: 1459 year: 1993 end-page: 1463 article-title: Suppressive effect of antibody on processing of T cell epitopes publication-title: J Exp Med – volume: 281 start-page: 646 year: 1979 end-page: 650 article-title: Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli publication-title: Nature – volume: 145 start-page: 3442 year: 1990 end-page: 3449 article-title: Cellular immune response to hepatitis B virus‐encoded antigens in acute and chronic hepatitis B virus infection publication-title: J Immunol – start-page: 1‐63 end-page: 100 – volume: 33 start-page: 963 year: 2001 end-page: 971 article-title: Lamivudine treatment can overcome cytotoxic T‐cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy publication-title: Hepatology – volume: 443 start-page: 350 year: 2006 end-page: 354 article-title: PD‐1 expression on HIV‐specific T cells is associated with T‐cell exhaustion and disease progression publication-title: Nature – start-page: 78 year: 2004 article-title: Consistent cytotoxic‐T‐lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities publication-title: J Virol – volume: 98 start-page: 1185 year: 1996 end-page: 1194 article-title: Long‐lasting memory T cell responses following self‐limited acute hepatitis B publication-title: J Clin Invest – volume: 81 start-page: 4215 year: 2007 end-page: 4225 article-title: Characterization of HBV‐specific T cell dysfunction in chronic HBV infection publication-title: J Virol – volume: 78 start-page: 4463 year: 2004 end-page: 4477 article-title: Comprehensive analysis of human immunodeficiency virus type 1‐specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides publication-title: J Virol – volume: 13 start-page: 46 year: 2007 end-page: 53 article-title: CD8+ T‐cell responses to different HIV proteins have discordant associations with viral load publication-title: Nat Med – volume: 37 start-page: 4350 year: 2005 end-page: 4353 article-title: Liver transplantation for hepatitis B in the United States publication-title: Transplant Proc – volume: 20 start-page: 351 year: 2006 end-page: 358 article-title: Reactivation of hepatitis and lamivudine therapy in 11 HBsAg‐positive renal allograft recipients: a single centre experience publication-title: Clin Transplant – volume: 192 start-page: 622 year: 2005 end-page: 629 article-title: Impact of Kaposi sarcoma‐associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins publication-title: J Infect Dis – volume: 10 start-page: S74 year: 2004 end-page: S85 article-title: Evolving strategies to prevent HBV recurrence publication-title: Liver Transpl – volume: 14 start-page: 29 issue: Suppl 2 year: 2000 end-page: 38 article-title: Pharmacoeconomic analysis of HBV liver transplant therapies publication-title: Clin Transplant – volume: 34 start-page: 903 year: 2001 end-page: 910 article-title: Prevention of hepatitis B virus recurrence after liver transplantation in cirrhotic patients treated with lamivudine and passive immunoprophylaxis publication-title: J Hepatol – volume: 96 start-page: 447 year: 1982 end-page: 449 article-title: Reactivation of chronic hepatitis B virus infection by cancer chemotherapy publication-title: Ann Intern Med – volume: 69 start-page: 559 year: 2000 end-page: 568 article-title: Immunopathogenesis of hepatitis B virus recurrence after liver transplantation publication-title: Transplantation – volume: 39 start-page: 595 year: 2003 end-page: 605 article-title: Transient restoration of anti‐viral T cell responses induced by lamivudine therapy in chronic hepatitis B publication-title: J Hepatol – volume: 181 start-page: 1957 year: 1995 end-page: 1963 article-title: Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants publication-title: J Exp Med – volume: 181 start-page: 1047 year: 1995 end-page: 1058 article-title: The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis publication-title: J Exp Med – volume: 81 start-page: 4904 year: 2007 end-page: 4908 article-title: Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma‐associated herpesvirus and Epstein‐Barr virus induce T‐cell responses with similar functional properties and memory phenotypes publication-title: J Virol – volume: 77 start-page: 195 year: 1991 end-page: 200 article-title: Allogeneic marrow transplantation in patients positive for hepatitis B surface antigen publication-title: Blood – volume: 173 start-page: 5355 year: 2004 end-page: 5359 article-title: Cutting edge: identification of hepatitis C virus‐specific CD8+ T cells restricted by donor HLA alleles following liver transplantation publication-title: J Immunol – volume: 11 start-page: 716 year: 2005 end-page: 732 article-title: Management of the hepatitis B virus in the liver transplantation setting: a European and an American perspective publication-title: Liver Transpl – volume: 2 start-page: 1104 year: 1996 end-page: 1108 article-title: The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T‐lymphocyte response publication-title: Nat Med – volume: 93 start-page: 230 year: 1994 end-page: 239 article-title: Hepatitis B virus persistence after recovery from acute viral hepatitis publication-title: J Clin Invest – volume: 37 start-page: 2419 year: 2007 end-page: 2433 article-title: Extensive HLA class I allele promiscuity among viral CTL epitopes publication-title: Eur J Immunol – volume: 191 start-page: 1269 year: 2000 end-page: 1280 article-title: The role of virus‐specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection publication-title: J Exp Med – volume: 78 start-page: 5707 year: 2004 end-page: 5719 article-title: Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy publication-title: J Virol – volume: 203 start-page: 437 year: 2006 end-page: 447 article-title: Complete differentiation of CD8+ T cells activated locally within the transplanted liver publication-title: J Exp Med – volume: 18 start-page: 871 year: 2004 end-page: 876 article-title: Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels publication-title: AIDS – volume: 21 start-page: 1245 year: 2007 end-page: 1252 article-title: Kaposi's sarcoma‐associated herpesvirus‐specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C‐infected individuals with Kaposi's sarcoma publication-title: AIDS – volume: 3 start-page: 20 year: 2005 article-title: Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, anti‐CD3 mAb T‐cell expansion and “RecycleSpot” publication-title: J Transl Med – volume: 38 start-page: 4 year: 2003 end-page: 13 article-title: Kinetics of the immune response during HBV and HCV infection publication-title: Hepatology – volume: 176 start-page: 157 year: 1992 end-page: 168 article-title: Identification of target antigens for the human cytotoxic T cell response to Epstein‐Barr virus (EBV): implications for the immune control of EBV‐positive malignancies publication-title: J Exp Med – volume: 97 start-page: 1655 year: 1996 end-page: 1665 article-title: Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection publication-title: J Clin Invest – volume: 102 start-page: 968 year: 1998 end-page: 975 article-title: Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B publication-title: J Clin Invest – volume: 192 start-page: 1513 year: 2005 end-page: 1524 article-title: Differential targeting and shifts in the immunodominance of Epstein‐Barr virus–specific CD8 and CD4 T cell responses during acute and persistent infection publication-title: J Infect Dis – volume: 20 start-page: 315 year: 2004 end-page: 325 article-title: Fine specificity and cross‐clade reactivity of HIV type 1 Gag‐specific CD4+ T cells publication-title: AIDS Res Hum Retroviruses – volume: 275 start-page: 19 year: 2003 end-page: 29 article-title: Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses publication-title: J Immunol Methods – volume: 83 start-page: 1267 year: 2002 end-page: 1280 article-title: Genetic variability in hepatitis B viruses publication-title: J Gen Virol – volume: 87 start-page: 1439 year: 2006 end-page: 1449 article-title: The immune response during hepatitis B virus infection publication-title: J Gen Virol – volume: 176 start-page: 157 year: 1992 ident: R33-13-20250326 article-title: Identification of target antigens for the human cytotoxic T cell response to EpsteinBarr virus (EBV): implications for the immune control of EBVpositive malignancies. publication-title: J Exp Med doi: 10.1084/jem.176.1.157 – volume: 34 start-page: 903 year: 2001 ident: R5-13-20250326 article-title: Prevention of hepatitis B virus recurrence after liver transplantation in cirrhotic patients treated with lamivudine and passive immunoprophylaxis. publication-title: J Hepatol doi: 10.1016/S0168-8278(01)00080-0 – volume: 77 start-page: 195 year: 1991 ident: R19-13-20250326 article-title: Allogeneic marrow transplantation in patients positive for hepatitis B surface antigen. publication-title: Blood doi: 10.1182/blood.V77.1.195.195 – volume: 81 start-page: 4904 year: 2007 ident: R30-13-20250326 article-title: 3rd, Henry LM, Suscovich TJ, Brown EE, et al. Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcomaassociated herpesvirus and EpsteinBarr virus induce Tcell responses with similar functional properties and memory phenotypes. publication-title: J Virol doi: 10.1128/JVI.02509-06 – volume: 37 start-page: 2419 year: 2007 ident: R29-13-20250326 article-title: Extensive HLA class I allele promiscuity among viral CTL epitopes. publication-title: Eur J Immunol doi: 10.1002/eji.200737365 – volume: 13 start-page: 46 year: 2007 ident: R36-13-20250326 article-title: CD8 Tcell responses to different HIV proteins have discordant associations with viral load. publication-title: Nat Med doi: 10.1038/nm1520 – volume: 18 start-page: 871 year: 2004 ident: R28-13-20250326 article-title: Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels. publication-title: AIDS doi: 10.1097/00002030-200404090-00004 – volume: 2 start-page: 1104 year: 1996 ident: R6-13-20250326 article-title: The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic Tlymphocyte response. publication-title: Nat Med doi: 10.1038/nm1096-1104 – volume: 81 start-page: 4215 year: 2007 ident: R13-13-20250326 article-title: Characterization of HBVspecific T cell dysfunction in chronic HBV infection. publication-title: J Virol doi: 10.1128/JVI.02844-06 – volume: 102 start-page: 968 year: 1998 ident: R14-13-20250326 article-title: Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. publication-title: J Clin Invest doi: 10.1172/JCI3731 – volume: 181 start-page: 1957 year: 1995 ident: R39-13-20250326 article-title: Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants. publication-title: J Exp Med doi: 10.1084/jem.181.6.1957 – volume: 78 start-page: 5707 year: 2004 ident: R12-13-20250326 article-title: Longitudinal analysis of CD8 T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. publication-title: J Virol doi: 10.1128/JVI.78.11.5707-5719.2004 – volume: 33 start-page: 963 year: 2001 ident: R16-13-20250326 article-title: Lamivudine treatment can overcome cytotoxic Tcell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. publication-title: Hepatology doi: 10.1053/jhep.2001.23045 – volume: 275 start-page: 19 year: 2003 ident: R23-13-20250326 article-title: Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses. publication-title: J Immunol Methods doi: 10.1016/S0022-1759(02)00541-0 – volume: 178 start-page: 1459 year: 1993 ident: R40-13-20250326 article-title: Suppressive effect of antibody on processing of T cell epitopes. publication-title: J Exp Med doi: 10.1084/jem.178.4.1459 – volume: 93 start-page: 230 year: 1994 ident: R34-13-20250326 article-title: Hepatitis B virus persistence after recovery from acute viral hepatitis. publication-title: J Clin Invest doi: 10.1172/JCI116950 – volume: 21 start-page: 1245 year: 2007 ident: R31-13-20250326 article-title: 3rd, Dollard S, Gumbi P, et al. Kaposi's sarcomaassociated herpesvirusspecific immune reconstitution and antiviral effect of combined HAARTchemotherapy in HIV clade Cinfected individuals with Kaposi's sarcoma. publication-title: AIDS doi: 10.1097/QAD.0b013e328182df03 – volume: 192 start-page: 622 year: 2005 ident: R38-13-20250326 article-title: Impact of Kaposi sarcomaassociated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins. publication-title: J Infect Dis doi: 10.1086/432103 – volume: 97 start-page: 1655 year: 1996 ident: R8-13-20250326 article-title: Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection. publication-title: J Clin Invest doi: 10.1172/JCI118592 – volume: 20 start-page: 351 year: 2006 ident: R17-13-20250326 article-title: Reactivation of hepatitis and lamivudine therapy in 11 HBsAgpositive renal allograft recipients: a single centre experience. publication-title: Clin Transplant doi: 10.1111/j.1399-0012.2006.00490.x – volume: 3 start-page: 20 year: 2005 ident: R20-13-20250326 article-title: 3rd, Hewitt HS, Henry LM, Linde C, et al. Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, antiCD3 mAb Tcell expansion and RecycleSpot. publication-title: J Transl Med doi: 10.1186/1479-5876-3-20 – volume: 87 start-page: 1439 year: 2006 ident: R35-13-20250326 article-title: The immune response during hepatitis B virus infection. publication-title: J Gen Virol doi: 10.1099/vir.0.81920-0 – volume: 281 start-page: 646 year: 1979 ident: R24-13-20250326 article-title: Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. publication-title: Nature doi: 10.1038/281646a0 – volume: 173 start-page: 5355 year: 2004 ident: R44-13-20250326 article-title: Cutting edge: identification of hepatitis C virusspecific CD8 T cells restricted by donor HLA alleles following liver transplantation. publication-title: J Immunol doi: 10.4049/jimmunol.173.9.5355 – volume: 181 start-page: 1047 year: 1995 ident: R7-13-20250326 article-title: The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. publication-title: J Exp Med doi: 10.1084/jem.181.3.1047 – volume: 96 start-page: 447 year: 1982 ident: R18-13-20250326 article-title: Reactivation of chronic hepatitis B virus infection by cancer chemotherapy. publication-title: Ann Intern Med doi: 10.7326/0003-4819-96-4-447 – volume: 14 start-page: 29 issue: Suppl 2 year: 2000 ident: R3-13-20250326 article-title: Pharmacoeconomic analysis of HBV liver transplant therapies. publication-title: Clin Transplant – volume: 37 start-page: 4350 year: 2005 ident: R2-13-20250326 article-title: Liver transplantation for hepatitis B in the United States. publication-title: Transplant Proc doi: 10.1016/j.transproceed.2005.10.017 – volume: 98 start-page: 1185 year: 1996 ident: R9-13-20250326 article-title: Longlasting memory T cell responses following selflimited acute hepatitis B. publication-title: J Clin Invest doi: 10.1172/JCI118902 – volume: 20 start-page: 315 year: 2004 ident: R27-13-20250326 article-title: Fine specificity and crossclade reactivity of HIV type 1 Gagspecific CD4 T cells. publication-title: AIDS Res Hum Retroviruses doi: 10.1089/088922204322996554 – volume: 443 start-page: 350 year: 2006 ident: R41-13-20250326 article-title: PD1 expression on HIVspecific T cells is associated with Tcell exhaustion and disease progression. publication-title: Nature doi: 10.1038/nature05115 – volume: 10 start-page: S74 year: 2004 ident: R4-13-20250326 article-title: Evolving strategies to prevent HBV recurrence. publication-title: Liver Transpl doi: 10.1002/lt.20258 – volume: 38 start-page: 4 year: 2003 ident: R10-13-20250326 article-title: Kinetics of the immune response during HBV and HCV infection. publication-title: Hepatology doi: 10.1053/jhep.2003.50310 – volume: 83 start-page: 1267 year: 2002 ident: R25-13-20250326 article-title: Genetic variability in hepatitis B viruses. publication-title: J Gen Virol doi: 10.1099/0022-1317-83-6-1267 – volume: 11 start-page: 716 year: 2005 ident: R1-13-20250326 article-title: Management of the hepatitis B virus in the liver transplantation setting: a European and an American perspective. publication-title: Liver Transpl doi: 10.1002/lt.20492 – volume: 39 start-page: 595 year: 2003 ident: R15-13-20250326 article-title: Transient restoration of antiviral T cell responses induced by lamivudine therapy in chronic hepatitis B. publication-title: J Hepatol doi: 10.1016/S0168-8278(03)00292-7 – volume: 69 start-page: 559 year: 2000 ident: R42-13-20250326 article-title: Immunopathogenesis of hepatitis B virus recurrence after liver transplantation. publication-title: Transplantation doi: 10.1097/00007890-200002270-00017 – volume: 191 start-page: 1269 year: 2000 ident: R11-13-20250326 article-title: The role of virusspecific CD8() cells in liver damage and viral control during persistent hepatitis B virus infection. publication-title: J Exp Med doi: 10.1084/jem.191.8.1269 – volume: 192 start-page: 1513 year: 2005 ident: R37-13-20250326 article-title: Differential targeting and shifts in the immunodominance of EpsteinBarr virus-specific CD8 and CD4 T cell responses during acute and persistent infection. publication-title: J Infect Dis doi: 10.1086/491741 – volume: 78 start-page: 4463 year: 2004 ident: R26-13-20250326 article-title: Comprehensive analysis of human immunodeficiency virus type 1specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides. publication-title: J Virol doi: 10.1128/JVI.78.9.4463-4477.2004 – volume: 203 start-page: 437 year: 2006 ident: R43-13-20250326 article-title: Complete differentiation of CD8 T cells activated locally within the transplanted liver. publication-title: J Exp Med doi: 10.1084/jem.20051775 – volume: 145 start-page: 3442 year: 1990 ident: R32-13-20250326 article-title: Cellular immune response to hepatitis B virusencoded antigens in acute and chronic hepatitis B virus infection. publication-title: J Immunol doi: 10.4049/jimmunol.145.10.3442 |
| SSID | ssj0011590 |
| Score | 1.8946366 |
| Snippet | Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft‐ and patient‐survival. Treatment with... Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) is associated with poor graft- and patient-survival. Treatment with... |
| SourceID | proquest pubmed crossref wiley |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 478 |
| SubjectTerms | Antibody Specificity CD4 antigen Chronic infection Cyclosporine - therapeutic use Data processing Differentiation DNA, Viral - analysis Envelope protein Hepatitis B - immunology Hepatitis B e Antigens - blood Hepatitis B Surface Antigens - blood Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B, Chronic - immunology Humans Immunity Immunity (cell-mediated) Immunoglobulins Immunosuppressive Agents - therapeutic use Liver transplantation Liver Transplantation - immunology Lymphocytes - immunology Lymphocytes T Nucleocapsid - immunology Nucleocapsids Recurrence T-Lymphocytes - immunology Tacrolimus - therapeutic use Viral Load Viremia |
| Title | Sustained and focused hepatitis B virus nucleocapsid–specific T‐cell immunity in liver transplant recipients compared to individuals with chronic and self‐limited hepatitis B virus infection |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Flt.21384 https://www.ncbi.nlm.nih.gov/pubmed/18324666 https://www.proquest.com/docview/70464358 https://www.proquest.com/docview/902339333 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LatwwFBUli9JN3w_3eQulXXkyY8myvewrhNJ00U4g0IWxHiamxjPEcqFd5RMK_aV-Sb6k90r2hLQJlK4sg2zJ1tXVkXTuEWPPEPSq2oo0VlapWGRzHReirmKRLgw6P20yH-W690Hu7ot3B-nByKqkWJigD7FZcKOe4f01dfBK9dunoqGtmyULnpMU6IJLks1_83GjHIU4xy-v0KGtsRQynXRn58n29ODZkegveHkWrfrhZuca-zxVNLBMvswGp2b6-x8ajv_3JdfZ1RGFwstgNjfYJdvdZJf3xn32W-zXpxBXZQ1UnYF6pYce04eW-Neu6eEVfG2Ohh46kkPG4XCNRn1y_JPiNol7BMuT4x-0JwCNjz9x36DpoCUOCDgvp95iiwIpa6wpILOHiQsPbgXNJkisB1onBh0UfH1detvW-PI2BGadU6WJXtbdZvs7b5evd-PxvIdY8zwVcS4NgpUiMXWlMoOuCKc7WWJ0lVQ4D5WKK8nxJpsbkWqhJKKPtMKUKDJ0RYnld9hWt-rsPQbWzGtZa6V1roSovUaOIKPEwTgptInYi6ntSz2KodOZHG0ZZJyTsnWlb5SIPd3kXAcBkHPyPJnMp8TeSb-36uxq6MuMdo55mkcMLshRIGjiBec8YneD4Z0Wg95W4PQyYs-9-VxYfvl-6a_3_zXjA3Yl8F6IgfSQbbmjwT5CcOXUY9-NfgPwaSfX |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIgGXlldpKFAjIThlu42dlzjxqhbY7QG2Ug9IUfyIiIiyqyapVE79CUj8JX5Jfwkz9marQishTnGkSezE4_E39sxngGcIemVhROhLI6Uv4qHyU1Hkvgh3NRo_pWOb5TrZj0YH4sNheLgCL_tcGMcPsVxwo5Fh7TUNcFqQ3jlnDa3aQbDLE3ENrgvEGeR5vf205I5CpGMXWOjYVj9CgZ55dhjs9E9enIv-ApgX8aqdcPbW4UvfVBdn8m3QtXKgvv_B4vif33Ib1hZAlL1ymnMHVkx9F25MFlvt9-DXZ5daZTTLa82KmeoaLH81FILdlg17zY7Lo65hNTEi44w4R70-O_1JqZsUfsSmZ6c_aFuAlTYFpT1hZc0qCgNhrWVUr7BTGZFrzCkns2F9ODxrZ6xc5ok1jJaKmXIkvrYtjakKfHnlcrMuaVIfYVbfh4O9d9M3I39x5IOveBIKP4k04pU00EUuY43WCD2eONAqD3J0RSPJZcTxJh5qESohIwQgYY4lkcZojQLDN2C1ntVmE5jRwyIqlFQqkUIUliZHkF7ifBykSnvwou_8TC340OlYjipzTM5BVrWZ7RQPni4l544D5BKZ7V5_Mhyg9Hvz2sy6Jotp85iHiQfsCokUcRNPOecePHCad14NGlyBHqYHz63-XFl_Np7a68N_FdyGm6PpZJyN3-9_3IJbLgyGApIewWp71JnHiLVa-cSOqd9DIyv2 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3ZbtQwFLWgSBUv7EvYepEQPGU6jZ3tkW1UoK0QTKVKPETxJiKizKhJkOCpn4DEL_El_RLutZOpCq2EeIojObETX18f2-ceM_YEQa-0RsShNFKGIp2qMBe2DEW8pdH5KZ26KNfdvWR7X7w9iA8GViXFwnh9iNWCG_UM56-pgy-13TwRDa27SbTFM3GRXRIJAgkCRB9W0lEIdNz6Cp3aGiYiiUfh2Wm0OT55eij6C1-ehqtuvJldZZ_GmnqayZdJ38mJ-v6HiOP_fco1dmWAofDc2811dsE0N9j67rDRfpP9-ugDq4yGstFgF6pvMf3ZEAG7q1p4AV-rw76FhvSQcTxcolUfH_2kwE0iH8H8-OgHbQpA5QJQum9QNVATCQQ6p6deY5MCSWssKSKzhZEMD90CqlWUWAu0UAzKS_i6urSmtvjy2kdmnVGlkV_W3GL7s9fzl9vhcOBDqHgWizBLNKKVPNK2lKlGX4TznTTSqoxKnIgmksuE40061SJWQiYIP-ISUyJP0RdFht9ma82iMXcZGD21iVVSqUwKYZ1IjiCrxNE4ypUO2LOx7Qs1qKHToRx14XWco6LuCtcoAXu8yrn0CiBn5NkYzafA7km_t2zMom-LlLaOeZwFDM7JkSNq4jnnPGB3vOGdFIPuVuD8MmBPnfmcW36xM3fXe_-acYOtv381K3be7L27zy57DgyxkR6wte6wNw8RaHXyketRvwG1Jyql |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sustained+and+focused+hepatitis+B+virus+nucleocapsid-specific+T-cell+immunity+in+liver+transplant+recipients+compared+to+individuals+with+chronic+and+self-limited+hepatitis+B+virus+infection&rft.jtitle=Liver+transplantation&rft.au=Bihl%2C+Florian&rft.au=Loggi%2C+Elisabetta&rft.au=Chisholm%2C+3rd%2C+John+V&rft.au=Biselli%2C+Maurizio&rft.date=2008-04-01&rft.eissn=1527-6473&rft.volume=14&rft.issue=4&rft.spage=478&rft_id=info:doi/10.1002%2Flt.21384&rft_id=info%3Apmid%2F18324666&rft.externalDocID=18324666 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1527-6465&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1527-6465&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1527-6465&client=summon |