Transcriptional downregulation of miR‐127‐3p by CTCF promotes prostate cancer bone metastasis by targeting PSMB5

• Published in: FEBS letters Vol. 594; no. 3; pp. 466 - 476
• Main Authors: Fan, Jiaxing, Du, Wenzhi, Zhang, Hui, Wang, Yunchao, Li, Kai, Meng, Yong, Wang, Jianning
• Format: Journal Article
• Language: English
• Published: England 01.02.2020
• Subjects: bone metastasis; CTCF; miR‐127‐3p; prostate cancer; PSMB5; prostate cancer; PSMB5; CTCF; bone metastasis; miR-127-3p

Prostate cancer (PCa) is one of the most common cancers in males and particularly tends to metastasize to bone. Currently, metastatic bone disease is incurable, and new therapies need to be developed. Our study aims to determine the role of miR‐127‐3p in PCa metastasis to bone. The results demonstra...