Diffuse large B-cell lymphoma with fibrillary matrix

• Published in: Diagnostic cytopathology Vol. 27; no. 4; pp. 223 - 226
• Main Authors: Dargent, Jean-Louis, Meiers, Isabelle, Lespagnard, Laurence, Ma, Yan, Dehou, Marie-Françoise, Verhest, Alain
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.10.2002; Wiley-Liss
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Biopsy, Needle; Cyclophosphamide - administration & dosage; diffuse large B-cell lymphoma; Doxorubicin - administration & dosage; Extracellular Matrix - pathology; Female; fibrillary matrix; Flow Cytometry; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymph Nodes - pathology; lymphoma; Lymphoma, B-Cell - drug therapy; Lymphoma, B-Cell - pathology; Lymphoma, Large B-Cell, Diffuse - drug therapy; Lymphoma, Large B-Cell, Diffuse - pathology; Medical sciences; microvillous lymphoma; Prednisone - administration & dosage; Treatment Outcome; Vincristine - administration & dosage; Human; Diffuse; Immunohistochemistry; Stroma; Malignant hemopathy; B-Lymphocyte; Large cell lymphoma; Fibrillar structure; Non Hodgkin lymphoma; Electron microscopy; Fine needle aspiration biopsy; Case study; Polymerase chain reaction; Pathology; Lymphoproliferative syndrome; Cytopathology; Female; Interstitial; Molecular biology; Elderly
• ISSN: 8755-1039; 1097-0339
• DOI: 10.1002/dc.10172

Diffuse large B‐cell lymphoma (DLBCL) with fibrillary matrix is an extremely rare variant of non‐Hodgkin's lymphoma (NHL) whose pathological features are poorly known. Here, we report on our experience with such a condition arising in a 71‐yr‐old woman. Our findings not only demonstrate that DLBCL with fibrillary matrix actually represents a peculiar subtype of DLBCL, but they also illustrate that the cytologic and flow cytometric features in this disorder can be deceptive enough as to mislead even the most experienced cytopathologist. Diagn. Cytopathol. 2002;27:223–226. © 2002 Wiley‐Liss, Inc.