Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress

• Published in: Frontiers in cellular neuroscience Vol. 15; p. 639322
• Main Authors: Dias, Liliana, Lopes, Cátia R., Gonçalves, Francisco Q., Nunes, Ana, Pochmann, Daniela, Machado, Nuno J., Tomé, Angelo R., Agostinho, Paula, Cunha, Rodrigo A.
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 01.03.2021; Frontiers Media S.A
• Subjects: Adenosine; adenosine A2A receptor; Adenosine A2A receptors; Agonists; Animals; ATP P2X7 receptor; behavior; Blood-brain barrier; Caffeine; Calcium; Cellular Neuroscience; Drug dosages; Hedonic response; Inflammation; Interleukin 1; Mental depression; Microglia; mRNA; neuroinflammation; Neuroprotection; Prefrontal cortex; Rodents; stress; Thigmotaxis; Portugal

Depressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P 2X7 receptors (P 2X7 R) and adenosine A 2A receptors (A 2A R) antagonists attenuate behavioral modifications upon exposure to repeated stress. Since it i...