Histologic evaluation of fresh human ovarian tissue before cryopreservation
Transplantation of cryopreserved tissue from patients with cancer may carry the risk of reactivation or redissemination of micrometastases. This prospective study was conducted to evaluate the potential involvement of micrometastases in ovarian tissue in cancer patients. Ovarian biopsies were collec...
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Published in | International journal of gynecological pathology Vol. 29; no. 1; p. 19 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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01.01.2010
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Abstract | Transplantation of cryopreserved tissue from patients with cancer may carry the risk of reactivation or redissemination of micrometastases. This prospective study was conducted to evaluate the potential involvement of micrometastases in ovarian tissue in cancer patients. Ovarian biopsies were collected from patients who underwent ovarian tissue cryopreservation, in our IVF unit before chemotherapy between 2000 and 2008. Indications for cryopreservation included breast cancer (n=13), osteosarcoma (n=13), hematologic malignancies (n=13), uterine cervix carcinoma (n=2), endometrial carcinoma (n=1), colon cancer (n=1), and brain medulloblastoma (n=1). The samples were stained with hematoxylin and eosin, and examined histologically. Immunoperoxidase broad-spectrum cytokeratin staining was also performed on specimens from breast cancer patients. There were 44 patients (age range 5-40 yr) who yielded 40 specimens. No gross pathologic involvement was observed, and the histologic examination revealed normal histology with no evidence of metastases. Our findings showed that for the purpose of considering ovarian tissue cryopreservation in cancer patients, the likelihood of microscopic metastases within ovaries of normal appearance is apparently very low. Clarification of the actual risk of ovarian involvement and any subsequent risk of micrometastases and tumor reimplantation requires further investigation. |
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AbstractList | Transplantation of cryopreserved tissue from patients with cancer may carry the risk of reactivation or redissemination of micrometastases. This prospective study was conducted to evaluate the potential involvement of micrometastases in ovarian tissue in cancer patients. Ovarian biopsies were collected from patients who underwent ovarian tissue cryopreservation, in our IVF unit before chemotherapy between 2000 and 2008. Indications for cryopreservation included breast cancer (n=13), osteosarcoma (n=13), hematologic malignancies (n=13), uterine cervix carcinoma (n=2), endometrial carcinoma (n=1), colon cancer (n=1), and brain medulloblastoma (n=1). The samples were stained with hematoxylin and eosin, and examined histologically. Immunoperoxidase broad-spectrum cytokeratin staining was also performed on specimens from breast cancer patients. There were 44 patients (age range 5-40 yr) who yielded 40 specimens. No gross pathologic involvement was observed, and the histologic examination revealed normal histology with no evidence of metastases. Our findings showed that for the purpose of considering ovarian tissue cryopreservation in cancer patients, the likelihood of microscopic metastases within ovaries of normal appearance is apparently very low. Clarification of the actual risk of ovarian involvement and any subsequent risk of micrometastases and tumor reimplantation requires further investigation. |
Author | Almog, Beni Ben-Yosef, Dalit Lessing, Joseph B Kossoy, Nadia Hasson, Joseph Lifschitz-Mercer, Batriz Cohen, Tanya Azem, Foad Amit, Ami |
Author_xml | – sequence: 1 givenname: Foad surname: Azem fullname: Azem, Foad email: Azemf@tasmc.health.gov.il organization: Racine IVF Unit, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Azemf@tasmc.health.gov.il – sequence: 2 givenname: Joseph surname: Hasson fullname: Hasson, Joseph – sequence: 3 givenname: Dalit surname: Ben-Yosef fullname: Ben-Yosef, Dalit – sequence: 4 givenname: Nadia surname: Kossoy fullname: Kossoy, Nadia – sequence: 5 givenname: Tanya surname: Cohen fullname: Cohen, Tanya – sequence: 6 givenname: Beni surname: Almog fullname: Almog, Beni – sequence: 7 givenname: Ami surname: Amit fullname: Amit, Ami – sequence: 8 givenname: Joseph B surname: Lessing fullname: Lessing, Joseph B – sequence: 9 givenname: Batriz surname: Lifschitz-Mercer fullname: Lifschitz-Mercer, Batriz |
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Snippet | Transplantation of cryopreserved tissue from patients with cancer may carry the risk of reactivation or redissemination of micrometastases. This prospective... |
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SubjectTerms | Bone Neoplasms - pathology Breast Neoplasms - secondary Cerebellar Neoplasms - pathology Colonic Neoplasms - pathology Cryopreservation Endometrial Neoplasms - pathology Female Fertility Hematologic Neoplasms - pathology Humans Infertility, Female - etiology Infertility, Female - prevention & control Medulloblastoma - secondary Osteosarcoma - secondary Ovarian Neoplasms - secondary Ovary - pathology Ovary - transplantation Primary Ovarian Insufficiency - etiology Primary Ovarian Insufficiency - prevention & control Transplantation, Autologous Uterine Neoplasms - pathology |
Title | Histologic evaluation of fresh human ovarian tissue before cryopreservation |
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