CGH and CD 44/MIB-1 immunohistochemistry are helpful to distinguish metastasized from nonmetastasized sporadic pheochromocytomas

• Published in: Modern pathology Vol. 17; no. 9; pp. 1119 - 1128
• Main Authors: August, Christian, August, Kathrein, Schroeder, Soeren, Bahn, Hannes, Hinze, Raoul, Baba, Hideo A, Kersting, Christian, Buerger, Horst
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2004; Elsevier Limited
• Subjects: Adolescent; Adrenal Gland Neoplasms - genetics; Adrenal Gland Neoplasms - metabolism; Adrenal Gland Neoplasms - pathology; Adult; Aged; Aged, 80 and over; CD 44; CGH; Chromosome Aberrations; Diagnosis, Differential; Female; Humans; Hyaluronan Receptors - analysis; Immunohistochemistry; Ki-67 Antigen - analysis; Male; MIB-1; Middle Aged; Neoplasm Metastasis - diagnosis; Nucleic Acid Hybridization - methods; pheochromocytoma; Pheochromocytoma - genetics; Pheochromocytoma - metabolism; Pheochromocytoma - pathology; predictive factors; CD 44; pheochromocytoma; immunohistochemistry; CGH; MIB-1; predictive factors

The natural course of pheochromocytomas (PCC) cannot be predicted for certain on the basis of primary histology, their malignant character can only be confirmed by the occurrence of metastases during follow-up. Based on the recently proposed PASS score for evaluation we examined 37 adrenal (36 spora...