Microparticles Produced by Activated Platelets Carry a Potent and Functionally Active Angiogenic Signal in Subjects with Crohn’s Disease

• Published in: International journal of molecular sciences Vol. 19; no. 10; p. 2921
• Main Authors: Gaetani, Eleonora, Del Zompo, Fabio, Marcantoni, Margherita, Gatto, Ilaria, Giarretta, Igor, Porfidia, Angelo, Scaldaferri, Franco, Laterza, Lucrezia, Lopetuso, Loris, Gasbarrini, Antonio, Pola, Roberto
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 26.09.2018
• Subjects: Adult; Blood Platelets - metabolism; Cell-Derived Microparticles - genetics; Cell-Derived Microparticles - metabolism; Crohn Disease - blood; Crohn Disease - genetics; Crohn Disease - metabolism; Endothelial Cells - drug effects; Endothelial Cells - physiology; Female; Growth Substances - genetics; Growth Substances - metabolism; Growth Substances - pharmacology; Humans; Male; Middle Aged; Neovascularization, Physiologic - drug effects; Neovascularization, Physiologic - genetics; Platelet Activation; RNA, Messenger - genetics; RNA, Messenger - metabolism; Vascular Endothelial Growth Factor A - pharmacology; microparticles; angiogenesis; Crohn’s disease

Microparticles (MPs) are submicron vesicles shed from various cell types upon activation, stimulation, and death. Activated platelets are an important source of circulating MPs in subjects with inflammatory diseases, including Crohn’s disease (CD). Angiogenesis is a hallmark of inflammation in CD an...