The effect of high-flow nasal cannula in reducing the mortality and the rate of endotracheal intubation when used before mechanical ventilation compared with conventional oxygen therapy and noninvasive positive pressure ventilation. A systematic review and meta-analysis

• Published in: The American journal of emergency medicine Vol. 36; no. 2; pp. 226 - 233
• Main Authors: Ni, Yue-Nan, Luo, Jian, Yu, He, Liu, Dan, Liang, Bin-Miao, Liang, Zong-An
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2018; Elsevier Limited
• Subjects: Bias; Cannula; Clinical trials; Clinical Trials as Topic; Critical Care - statistics & numerical data; Emergency medical care; Endotracheal intubation; Evidence-based medicine; High flow nasal cannula; Humans; Intubation; Intubation, Intratracheal - mortality; Intubation, Intratracheal - statistics & numerical data; Mechanical ventilation; Medical materials; Meta-analysis; Mortality; Oxygen; Oxygen Inhalation Therapy - methods; Oxygen Inhalation Therapy - mortality; Oxygen therapy; Positive-Pressure Respiration - methods; Positive-Pressure Respiration - mortality; Pressure; Respiration, Artificial - methods; Respiration, Artificial - mortality; Respiratory therapy; Systematic review; Ventilators; High flow nasal cannula; Mortality; Endotracheal intubation; Meta-analysis

The effects of high flow nasal cannula (HFNC) on adult patients when used before mechanical ventilation (MV) are unclear. We aimed to determine the effectiveness of HFNC when used before MV by comparison to conventional oxygen therapy (COT) and noninvasive positive pressure ventilation (NIPPV). The...