Impact of Hypothermic Temperature Control on Plasma and Soft Tissue Pharmacokinetics of Penicillin/Beta-Lactamase Inhibitor Combinations in Patients Resuscitated After Cardiac Arrest

• Published in: Clinical pharmacokinetics Vol. 64; no. 5; pp. 691 - 701
• Main Authors: Stommel, Alexandra-Maria, Matzneller, Peter, al Jalali, Valentin, Wulkersdorfer, Beatrix, Lackner, Edith, Mueller, Matthias, Dorn, Christoph, Holzer, Michael, Zeitlinger, Markus
• Format: Journal Article
• Language: English
• Published: Switzerland Springer Nature B.V 01.05.2025; Springer International Publishing
• Subjects: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination - administration & dosage; Amoxicillin-Potassium Clavulanate Combination - blood; Amoxicillin-Potassium Clavulanate Combination - pharmacokinetics; Ampicillin - blood; Ampicillin - pharmacokinetics; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Antibiotics; beta-Lactamase Inhibitors - administration & dosage; beta-Lactamase Inhibitors - blood; beta-Lactamase Inhibitors - pharmacokinetics; Body fat; Cardiac arrest; Catheters; Clinical medicine; Drug dosages; Ethics; Female; Heart Arrest - metabolism; Heart Arrest - therapy; Humans; Hypothermia; Hypothermia, Induced - methods; Intensive care; Lavage; Male; Middle Aged; Original; Penicillin; Pharmacokinetics; Plasma; Pneumonia; Prospective Studies; Resuscitation - methods; Sulbactam - administration & dosage; Sulbactam - blood; Sulbactam - pharmacokinetics; Urine; Ventilators; Austria; Vienna Austria

Penicillin/beta-lactamase inhibitors are often used to treat aspiration pneumonia in patients resuscitated after cardiac arrest (CA). The impact of hypothermic temperature control on the pharmacokinetics of amoxicillin/clavulanate (AMO/CLAV) and ampicillin/sulbactam (AMP/SULB) has not been studied....