Impact of Hypothermic Temperature Control on Plasma and Soft Tissue Pharmacokinetics of Penicillin/Beta-Lactamase Inhibitor Combinations in Patients Resuscitated After Cardiac Arrest - Stommel, Alexandra-Maria; Matzneller, Peter; al Jalali, Valentin; Wulkersdorfer, Beatrix; Lackner, Edith; Mueller, Matthias; Dorn, Christoph; Holzer, Michael; Zeitlinger, Markus (Clinical pharmacokinetics, 2025)
Keywords: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination - administration & dosage; Amoxicillin-Potassium Clavulanate Combination - blood; Amoxicillin-Potassium Clavulanate Combination - pharmacokinetics; Ampicillin - blood; Ampicillin - pharmacokinetics; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Antibiotics; beta-Lactamase Inhibitors - administration & dosage; beta-Lactamase Inhibitors - blood; beta-Lactamase Inhibitors - pharmacokinetics; Body fat; Cardiac arrest; Catheters; Clinical medicine; Drug dosages; Ethics; Female; Heart Arrest - metabolism; Heart Arrest - therapy; Humans; Hypothermia; Hypothermia, Induced - methods; Intensive care; Lavage; Male; Middle Aged; Original; Penicillin; Pharmacokinetics; Plasma; Pneumonia; Prospective Studies; Resuscitation - methods; Sulbactam - administration & dosage; Sulbactam - blood; Sulbactam - pharmacokinetics; Urine; Ventilators; Austria; Vienna Austria