Barriers to Infection of Human Cells by Feline Leukemia Virus: Insights into Resistance to Zoonosis

• Published in: Journal of virology Vol. 91; no. 5
• Main Authors: Terry, Anne, Kilbey, Anna, Naseer, Asif, Levy, Laura S., Ahmad, Shamim, Watts, Ciorsdaidh, Mackay, Nancy, Cameron, Ewan, Wilson, Sam, Neil, James C.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.03.2017
• Subjects: Animals; APOBEC-3G Deaminase - genetics; APOBEC-3G Deaminase - metabolism; Cats; Cell Line, Tumor; Disease Susceptibility; Gene Expression; Genome, Viral; HEK293 Cells; Humans; Leukemia Virus, Feline - physiology; Mutation; Retroviridae Infections - virology; Species Specificity; Viral Tropism; Virus Integration; Virus Replication; Virus-Cell Interactions; Zoonoses - virology; feline leukemia virus; restriction factors; zoonosis; APOBEC

The human genome displays a rich fossil record of past gammaretrovirus infections, yet no current epidemic is evident, despite environmental exposure to viruses that infect human cells in vitro . Feline leukemia viruses (FeLVs) rank high on this list, but neither domestic nor workplace exposure has...