Aspartato(1,2-cyclohexanediamine)platinum(II) complexes: synthesis and characterization; effects of minor impurities on antitumor activity

Aspartato(1,2-cyclohexanediamine)platinum(II) (ADP), where 1,2-cyclohexanediamine (DAC) is either trans- RR-, trans- SS-, meso- RS-, or a mixture of the three isomers (ADP mixture), has been synthesized and evaluated for antitumor activity. The structures of the complexes have been characterized by...

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Published inInorganica Chimica Acta Vol. 179; no. 2; pp. 281 - 287
Main Authors Talebian, Abdol H., Bensely, Dennis, Ghiorghis, Alem, Hammer, Charles F., Schein, Philip S., Green, Dianna
Format Journal Article
LanguageEnglish
Published Lausanne Elsevier B.V 15.01.1991
Elsevier Science
Subjects
Chemistry
Coordination compounds
Exact sciences and technology
Inorganic chemistry and origins of life
Preparations and properties
Antineoplastic agent
Divalent metal Complexes
COSY sequence
Organic ligand
Platinum «II» Complexes
Transition metal Complexes
Biological activity
Diamine
α-Aminoacid
Complexes Mixed
Preparation
Platinoid Complexes
NMR spectrum
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Abstract Aspartato(1,2-cyclohexanediamine)platinum(II) (ADP), where 1,2-cyclohexanediamine (DAC) is either trans- RR-, trans- SS-, meso- RS-, or a mixture of the three isomers (ADP mixture), has been synthesized and evaluated for antitumor activity. The structures of the complexes have been characterized by various spectroscopic techniques (IR, 1H, 13C, 195Pt and 2D-COSY ( 1H{ 1H}) and 2D-HETCOSY ( 1H{ 13C}) NMR). Purification and murine antitumor activity of the individual ADP isomers indicate that minor impurities in the ADP mixture have a significant effect on the potency of the platinum complexes.
AbstractList Aspartato(1,2-cyclohexanediamine)platinum(II) (ADP), where 1,2-cyclohexanediamine (DAC) is either trans- RR-, trans- SS-, meso- RS-, or a mixture of the three isomers (ADP mixture), has been synthesized and evaluated for antitumor activity. The structures of the complexes have been characterized by various spectroscopic techniques (IR, 1H, 13C, 195Pt and 2D-COSY ( 1H{ 1H}) and 2D-HETCOSY ( 1H{ 13C}) NMR). Purification and murine antitumor activity of the individual ADP isomers indicate that minor impurities in the ADP mixture have a significant effect on the potency of the platinum complexes.
Author Talebian, Abdol H.
Schein, Philip S.
Bensely, Dennis
Ghiorghis, Alem
Green, Dianna
Hammer, Charles F.
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10.1021/ic00304a004
10.1246/cl.1986.429
10.1007/BF00262274
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10.1248/cpb.35.221
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1991 INIST-CNRS
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Issue 2
Keywords Antineoplastic agent
Divalent metal Complexes
COSY sequence
Organic ligand
Platinum «II» Complexes
Transition metal Complexes
Biological activity
Diamine
α-Aminoacid
Complexes Mixed
Preparation
Platinoid Complexes
NMR spectrum
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Snippet Aspartato(1,2-cyclohexanediamine)platinum(II) (ADP), where 1,2-cyclohexanediamine (DAC) is either trans- RR-, trans- SS-, meso- RS-, or a mixture of the three...
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SubjectTerms Chemistry
Coordination compounds
Exact sciences and technology
Inorganic chemistry and origins of life
Preparations and properties
Title Aspartato(1,2-cyclohexanediamine)platinum(II) complexes: synthesis and characterization; effects of minor impurities on antitumor activity
URI https://dx.doi.org/10.1016/S0020-1693(00)85889-2
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