High Dimensional Immune Profiling of Smoldering Multiple Myeloma Distinguishes Distinct Tumor Microenvironments

• Published in: Clinical lymphoma, myeloma and leukemia Vol. 22; no. 11; pp. 853 - 862
• Main Authors: Fernandez, Nicolas, Perumal, Deepak, Rahman, Adeeb, Kim-Schulze, Seunghee, Yesil, Jen, Auclair, Daniel, Adams, Homer, Parekh, Samir, Gnjatic, Sacha, Cho, Hearn Jay
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.11.2022

Multiple myeloma (MM) is a malignancy of plasma cells that arises from premalignant Monoclonal Gammopathy of Undetermined Significance (MGUS) and often progresses through an asymptomatic Smoldering (SMM) phase. Understanding the interactions between abnormal clonal plasma cells and the tumor microen...