Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings

• Published in: Brain (London, England : 1878) Vol. 138; no. 12; pp. 3747 - 3759
• Main Authors: Jack, Clifford R., Wiste, Heather J., Weigand, Stephen D., Knopman, David S., Mielke, Michelle M., Vemuri, Prashanthi, Lowe, Val, Senjem, Matthew L., Gunter, Jeffrey L., Reyes, Denise, Machulda, Mary M., Roberts, Rosebud, Petersen, Ronald C.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2015
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloidosis - metabolism; Amyloidosis - pathology; Biomarkers - metabolism; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Cross-Sectional Studies; Female; Functional Neuroimaging; Hippocampus - metabolism; Hippocampus - pathology; Humans; Male; Middle Aged; Nerve Degeneration - diagnosis; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Neuropsychological Tests; Original; Positron-Emission Tomography; amyloid imaging; Alzheimer’s disease; preclinical Alzheimer’s disease; cognitive ageing; amyloid and neurodegeneration

We recently demonstrated that the frequencies of biomarker groups defined by the presence or absence of both amyloidosis (A+) and neurodegeneration (N+) changed dramatically by age in cognitively non-impaired subjects. Our present objectives were to assess the consequences of defining neurodegenerat...