Pharmaceutical cocrystallization: an effective approach to modulate the physicochemical properties of solid-state drugs

• Published in: CrystEngComm Vol. 2; no. 36; pp. 5292 - 5316
• Main Authors: Dai, Xia-Lin, Chen, Jia-Mei, Lu, Tong-Bu
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 2018
• Subjects: Cocrystallization; Drugs; Manufacturability; Molecular structure; Pharmaceuticals; Solid state

Pharmaceutical cocrystallization affords an opportunity to modify the physicochemical properties of a solid-state drug without covalent modification of its molecular structure. This review presents an update on various applications of pharmaceutical cocrystallization with considerations on both cocr...