Varying the ratio of Lys:Met while maintaining the ratios of Thr:Phe, Lys:Thr, Lys:His, and Lys:Val alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription

• Published in: Journal of dairy science Vol. 101; no. 2; pp. 1708 - 1718
• Main Authors: Dong, X., Zhou, Z., Saremi, B., Helmbrecht, A., Wang, Z., Loor, J.J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2018
• Subjects: lysine:methionine ratio; MAC-T cell; metabolomics; milk protein synthesis; MAC-T cell; lysine:methionine ratio; metabolomics; milk protein synthesis

Amino acids are not only precursors for but also signaling molecules regulating protein synthesis. Regulation of protein synthesis via AA occurs at least in part by alterations in the phosphorylation status of mammalian target of rapamycin (mTOR) pathway proteins. Although the ideal profile of Lys:M...