Highly Porous and Rigid, Full-thickness Human Skin Model from the Slime-webbed Fiber Scaffold
Collagen is the most prevalent scaffold material for in vitro skin models. The major limitation of collagen scaffold is its mechanical weakness, resulting in severe contraction during differentiation. Here, we presented a slime-webbed scaffold composed of perpendicularly stacked fibers with large po...
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| Published in | Biotechnology and bioprocess engineering Vol. 28; no. 2; pp. 246 - 254 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Seoul
The Korean Society for Biotechnology and Bioengineering
01.04.2023
Springer Nature B.V 한국생물공학회 |
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| Abstract | Collagen is the most prevalent scaffold material for
in vitro
skin models. The major limitation of collagen scaffold is its mechanical weakness, resulting in severe contraction during differentiation. Here, we presented a slime-webbed scaffold composed of perpendicularly stacked fibers with large pores. This slime-webbed scaffold did not contract while improving molecular transport and achieving comparable cell viability. Fibroblasts were seeded into the slime-webbed scaffold to mimic the dermal layer. In the epidermal layer, which was on top of this scaffold, keratinocytes expressed the differentiation biomarkers, keratin-5 and involucrin. Our slime-webbed scaffold-based human skin models overcome the critical limitations of collagen scaffold, suggesting a promising alternative skin model for consistent testing of drugs or cosmetic products. |
|---|---|
| AbstractList | Collagen is the most prevalent scaffold material for
in vitro
skin models. The major limitation of collagen scaffold is its mechanical weakness, resulting in severe contraction during differentiation. Here, we presented a slime-webbed scaffold composed of perpendicularly stacked fibers with large pores. This slime-webbed scaffold did not contract while improving molecular transport and achieving comparable cell viability. Fibroblasts were seeded into the slime-webbed scaffold to mimic the dermal layer. In the epidermal layer, which was on top of this scaffold, keratinocytes expressed the differentiation biomarkers, keratin-5 and involucrin. Our slime-webbed scaffold-based human skin models overcome the critical limitations of collagen scaffold, suggesting a promising alternative skin model for consistent testing of drugs or cosmetic products. Collagen is the most prevalent scaffold material for in vitro skin models. The major limitation of collagen scaffold is its mechanical weakness, resulting in severe contraction during differentiation. Here, we presented a slime-webbed scaffold composed of perpendicularly stacked fibers with large pores. This slime-webbed scaffold did not contract while improving molecular transport and achieving comparable cell viability. Fibroblasts were seeded into the slime-webbed scaffold to mimic the dermal layer. In the epidermal layer, which was on top of this scaffold, keratinocytes expressed the differentiation biomarkers, keratin-5 and involucrin. Our slime-webbed scaffold-based human skin models overcome the critical limitations of collagen scaffold, suggesting a promising alternative skin model for consistent testing of drugs or cosmetic products. Collagen is the most prevalent scaffold material for in vitro skin models. The major limitation of collagen scaffold is its mechanical weakness, resulting in severe contraction during differentiation. Here, we presented a slime-webbed scaffold composed of perpendicularly stacked fibers with large pores. This slime-webbed scaffold did not contract while improving molecular transport and achieving comparable cell viability. Fibroblasts were seeded into the slime-webbed scaffold to mimic the dermal layer. In the epidermal layer, which was on top of this scaffold, keratinocytes expressed the differentiation biomarkers, keratin-5 and involucrin. Our slime-webbed scaffold-based human skin models overcome the critical limitations of collagen scaffold, suggesting a promising alternative skin model for consistent testing of drugs or cosmetic products. KCI Citation Count: 0 |
| Author | Rhee, Jin-Kyu Ryu, Da Eun Kim, Ju Hyeon Ko, Byoung Ho Kim, Jae Jung Lee, Nam Keun Sung, Jong Hwan |
| Author_xml | – sequence: 1 givenname: Jae Jung surname: Kim fullname: Kim, Jae Jung organization: Department of Chemical Engineering, Hongik University – sequence: 2 givenname: Nam Keun surname: Lee fullname: Lee, Nam Keun organization: Department of Food Science and Biotechnology, Ewha Womans University – sequence: 3 givenname: Da Eun surname: Ryu fullname: Ryu, Da Eun organization: Department of Chemical Engineering, Hongik University – sequence: 4 givenname: Byoung Ho surname: Ko fullname: Ko, Byoung Ho organization: Department of Chemical Engineering, Hongik University – sequence: 5 givenname: Ju Hyeon surname: Kim fullname: Kim, Ju Hyeon organization: Department of Chemical Engineering, Hongik University – sequence: 6 givenname: Jin-Kyu surname: Rhee fullname: Rhee, Jin-Kyu email: jkrhee@ewha.ac.kr organization: Department of Food Science and Biotechnology, Ewha Womans University, SuFAB Inc – sequence: 7 givenname: Jong Hwan surname: Sung fullname: Sung, Jong Hwan email: jhsung22@hongik.ac.kr organization: Department of Chemical Engineering, Hongik University |
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| CitedBy_id | crossref_primary_10_1016_j_mtcomm_2024_109219 crossref_primary_10_1007_s12257_024_00094_6 crossref_primary_10_4103_apjtb_apjtb_865_23 |
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skin models. The major limitation of collagen scaffold is its mechanical weakness, resulting in... Collagen is the most prevalent scaffold material for in vitro skin models. The major limitation of collagen scaffold is its mechanical weakness, resulting in... |
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| Title | Highly Porous and Rigid, Full-thickness Human Skin Model from the Slime-webbed Fiber Scaffold |
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