Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

• Published in: The Journal of experimental medicine Vol. 218; no. 8
• Main Authors: Wilk, Aaron J., Lee, Madeline J., Wei, Bei, Parks, Benjamin, Pi, Ruoxi, Martínez-Colón, Giovanny J., Ranganath, Thanmayi, Zhao, Nancy Q., Taylor, Shalina, Becker, Winston, Vergara, Rosemary, McKechnie, Julia L., de la Parte, Lauren, Whittle Dantzler, Kathleen, Ty, Maureen, Kathale, Nimish, Martinez-Colon, Giovanny J., Rustagi, Arjun, Ivison, Geoff, Brewer, Rachel, Hollis, Taylor, Baird, Andrea, Ugur, Michele, Tal, Michal, Bogusch, Drina, Nahass, Georgie, Haider, Kazim, Thi Tran, Kim Quyen, Simpson, Laura, Din, Hena, Roque, Jonasel, Mann, Rosen, Chang, Iris, Do, Evan, Fernandes, Andrea, Lyu, Shu-Chen, Zhang, Wenming, Manohar, Monali, Krempski, James, Visweswaran, Anita, Zudock, Elizabeth J., Jee, Kathryn, Kumar, Komal, Newberry, Jennifer A., Quinn, James V., Schreiber, Donald, Ashley, Euan A., Blish, Catherine A., Blomkalns, Andra L., Nadeau, Kari C., O’Hara, Ruth, Rogers, Angela J., Yang, Samuel, Jimenez-Morales, David, Holmes, Susan, Rabinovitch, Marlene, Greenleaf, William J.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 02.08.2021
• Subjects: Adult; Aged; Case-Control Studies; Covid-19; COVID-19 - blood; COVID-19 - genetics; COVID-19 - immunology; COVID-19 - mortality; Cytokines - genetics; Epigenesis, Genetic; Female; Hematopoiesis; Humans; Immunity, Innate - physiology; Infectious Disease and Host Defense; Innate Immunity and Inflammation; Killer Cells, Natural - pathology; Killer Cells, Natural - virology; Male; Middle Aged; Monocytes - pathology; Monocytes - virology; Neutrophils - pathology; Neutrophils - virology; NF-kappa B - metabolism; Proteomics; Severity of Illness Index; Single-Cell Analysis

Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of patients at the extremes of the disease severity spectrum. Here, we performed multi-omic single-cell immune profiling o...