Triple-molded, reinforced arrowhead microneedle patch of dual human-derived matrix for integrated management of diabetic wounds

• Published in: Biomaterials Vol. 324; p. 123520
• Main Authors: Zhuang, Ze-Ming, Wang, Yong, Chen, Li, Wu, Zhang-Rui, Zhang, Tao, Bei, Ho-Pan, Feng, Zi-Xuan, Wang, Yi, Guo, Kai, Hsu, Yi-Ying, Chen, Jun, Du, Yong-Zhong, Chen, Jingdi, Zhao, Xin, Zhu, Ning-Wen, Tan, Wei-Qiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2026
• Subjects: Animals; Collagen - chemistry; Diabetes Mellitus, Experimental - complications; Diabetic wound; Humans; Hydrogels - chemistry; Male; Microneedle patch; Needles; Platelet-rich plasma; Platelet-Rich Plasma - chemistry; Rats; Rats, Sprague-Dawley; Recombinant human collagen; Skin regeneration; Wound Healing - drug effects; Skin regeneration; Recombinant human collagen; Diabetic wound; Platelet-rich plasma; Microneedle patch

Platelet-rich plasma (PRP) is often administered with gauze for wound management clinically. However, this treatment method suffers from poor contact, drug wastage and limited delivery depth compromising therapeutic efficacy. Local injections address some of these challenges but are invasive and cau...