CD32 + and PD-1 + Lymph Node CD4 T Cells Support Persistent HIV-1 Transcription in Treated Aviremic Individuals

• Published in: Journal of virology Vol. 92; no. 20
• Main Authors: Noto, Alessandra, Procopio, Francesco A., Banga, Riddhima, Suffiotti, Madeleine, Corpataux, Jean-Marc, Cavassini, Matthias, Riva, Agostino, Fenwick, Craig, Gottardo, Raphael, Perreau, Matthieu, Pantaleo, Giuseppe
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.10.2018
• Subjects: Adult; Anti-Retroviral Agents - therapeutic use; CD4-Positive T-Lymphocytes - chemistry; CD4-Positive T-Lymphocytes - virology; DNA, Viral - analysis; Female; HIV Infections - drug therapy; HIV Infections - pathology; HIV-1 - growth & development; Humans; Lymph Nodes - pathology; Male; Middle Aged; Pathogenesis and Immunity; Programmed Cell Death 1 Receptor - analysis; Receptors, IgG - analysis; RNA, Viral - analysis; T-Lymphocyte Subsets - chemistry; T-Lymphocyte Subsets - virology; Transcription, Genetic; Young Adult; human immunodeficiency virus; Tfh cells; PD-1; lymph node; CD32

The existence of long-lived latently infected resting memory CD4 T cells represents a major obstacle to the eradication of HIV infection. Identifying cell markers defining latently infected cells containing replication-competent virus is important in order to determine the mechanisms of HIV persiste...