Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells - Manzo, Teresa; Prentice, Boone M.; Anderson, Kristin G.; Raman, Ayush; Schalck, Aislyn; Codreanu, Gabriela S.; Nava Lauson, Carina B.; Tiberti, Silvia; Raimondi, Andrea; Jones, Marissa A.; Reyzer, Michelle; Bates, Breanna M.; et al. (The Journal of experimental medicine, 2020)
Keywords: Acyl-CoA Dehydrogenase, Long-Chain - biosynthesis; Acyl-CoA Dehydrogenase, Long-Chain - genetics; Animals; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; CD8-Positive T-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - pathology; Down-Regulation; Fatty Acids - genetics; Fatty Acids - metabolism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Lymphocytes, Tumor-Infiltrating - metabolism; Lymphocytes, Tumor-Infiltrating - pathology; Metabolism; Mice; Mice, Mutant Strains; Neoplasm Proteins - biosynthesis; Neoplasm Proteins - genetics; Pancreas - metabolism; Pancreas - pathology; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Tumor Immunology; Tumor Microenvironment