The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

• Published in: International journal of molecular sciences Vol. 22; no. 5; p. 2719
• Main Authors: Jang, Dan-in, Lee, A-Hyeon, Shin, Hye-Yoon, Song, Hyo-Ryeong, Park, Jong-Hwi, Kang, Tae-Bong, Lee, Sang-Ryong, Yang, Seung-Hoon
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 08.03.2021
• Subjects: Animals; Autoimmune Diseases - drug therapy; Autoimmune Diseases - immunology; Autoimmune Diseases - pathology; Chronic Disease; Humans; Immunologic Factors - therapeutic use; Review; Signal Transduction - drug effects; Signal Transduction - immunology; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - immunology; autoimmune diseases; psoriatic arthritis; TNF-α; rheumatoid arthritis; inflammatory bowel disease; TNF-α inhibitors

Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal tr...