Pharmacokinetics and non-analgesic effects of S- and R-ketamines in healthy volunteers with normal and reduced metabolic capacity

• Published in: European journal of clinical pharmacology Vol. 57; no. 12; pp. 869 - 875
• Main Authors: Persson, J., Hasselström, J., Maurset, A., Öye, I., Svensson, J.-O., Almqvist, O., Scheinin, H., Gustafsson, L.
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.02.2002; Berlin Springer Nature B.V
• Subjects: Adult; Analgesics; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biological and medical sciences; Cognition - drug effects; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 - physiology; Cytochrome P-450 Enzyme System - physiology; Hemodynamics - drug effects; Humans; Ketamine - pharmacokinetics; Male; Medical sciences; Middle Aged; Mixed Function Oxygenases - physiology; Neuropharmacology; Pharmacology. Drug treatments; Stereoisomerism; Human; Stereoisomer; Pharmacogenetics; Unspecific monooxygenase; Intravenous administration; Healthy subject; Enzyme; Cytochrome P450; Low dose; Metabolism; Absorption; Analgesic; Ketamine; General anesthetic; Gene; Structure activity relation; Distribution; Phenotype variation; Drug-metabolizing enzyme; Genetics; Stereospecificity; Oxidoreductases; Pharmacokinetics

There is a growing interest in low-dose ketamine as an analgesic agent in different intractable pain conditions. Due to its narrow therapeutic window, well-defined pharmacokinetic parameters are essential for its successful use in these situations. Arterial data for ketamine or its enantiomers have...