Pharmacokinetics and non-analgesic effects of S- and R-ketamines in healthy volunteers with normal and reduced metabolic capacity - Persson, J.; Hasselström, J.; Maurset, A.; Öye, I.; Svensson, J.-O.; Almqvist, O.; Scheinin, H.; Gustafsson, L. (European journal of clinical pharmacology, 2002)
Keywords: Adult; Analgesics; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biological and medical sciences; Cognition - drug effects; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 - physiology; Cytochrome P-450 Enzyme System - physiology; Hemodynamics - drug effects; Humans; Ketamine - pharmacokinetics; Male; Medical sciences; Middle Aged; Mixed Function Oxygenases - physiology; Neuropharmacology; Pharmacology. Drug treatments; Stereoisomerism; Human; Stereoisomer; Pharmacogenetics; Unspecific monooxygenase; Intravenous administration; Healthy subject; Enzyme; Cytochrome P450; Low dose; Metabolism; Absorption; Analgesic; Ketamine; General anesthetic; Gene; Structure activity relation; Distribution; Phenotype variation; Drug-metabolizing enzyme; Genetics; Stereospecificity; Oxidoreductases; Pharmacokinetics