3-Hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate inhibits HIV infection by blocking viral entry

• Published in: Journal of antimicrobial chemotherapy Vol. 68; no. 3; pp. 573 - 576
• Main Authors: Li, Lin, Qiu, Jiayin, Lu, Lu, An, Shengli, Qiao, Pengyuan, Jiang, Shibo, Liu, Shuwen
• Format: Journal Article
• Language: English
• Published: England Oxford Publishing Limited (England) 01.03.2013
• Subjects: Anti-Infective Agents - pharmacology; Antimicrobial agents; Antiviral activity; Antiviral agents; Cell growth; Cell Proliferation; Cells, Cultured; Cytotoxicity; Disease transmission; Drug resistance; Enzyme-linked immunosorbent assay; Epithelial cells; Epithelial Cells - drug effects; Epithelial Cells - virology; Female; gamma -Interferon; HIV; HIV Fusion Inhibitors - pharmacology; HIV-1 - drug effects; HIV-1 - physiology; Human immunodeficiency virus; Human immunodeficiency virus 1; human serum albumin; Humans; Hypersensitivity; Immunoassay; Immunogenicity; Infection; Infectivity; Interferon; Interferon-gamma - secretion; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - virology; microbicides; Ovalbumin; Peripheral blood mononuclear cells; Phthalic Anhydrides - pharmacology; Serum Albumin - pharmacology; Serum Albumin, Human; Vagina; Virus Internalization - drug effects

We recently demonstrated that both 3-hydroxyphthalic anhydride (HP)- and maleic anhydride-modified chicken ovalbumin (OVA) could effectively inhibit HIV-1 infection. But because OVA may cause allergy in some human subjects, here we replaced OVA with human serum albumin (HSA) in designing a new anti-...