Identification and characterization of cells with high angiogenic potential and transitional phenotype in calcific aortic valve

• Published in: Experimental cell research Vol. 313; no. 11; pp. 2326 - 2335
• Main Authors: Chalajour, Fariba, Treede, Hendrik, Gehling, Ursula M., Ebrahimnejad, Alireza, Boehm, Dieter H., Riemer, Robert K., Ergun, Suleyman, Reichenspurner, Hermann
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2007; Elsevier BV
• Subjects: Actins - metabolism; Angiogenesis; Antigens, CD - analysis; Aortic Valve - chemistry; Aortic Valve - metabolism; Aortic Valve - pathology; Aortic Valve Stenosis - genetics; Aortic Valve Stenosis - metabolism; Aortic Valve Stenosis - pathology; Biological Assay; Calcific aortic valve; Cardiovascular disease; Cells, Cultured; Cellular biology; Chemotaxis; Endothelial cells; Female; Flow Cytometry; Gene expression; Humans; Male; Molecular biology; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Organ Culture Techniques; Phenotype; Receptor, TIE-2 - metabolism; Smooth muscle cells; Transcription, Genetic; Vascular Endothelial Growth Factor A - pharmacology; Vascular Endothelial Growth Factor Receptor-2 - metabolism; Angiogenesis; Smooth muscle cells; Endothelial cells; Calcific aortic valve

Recent data suggest that angiogenesis plays an important role in the pathogenesis of valvular disease. However, the cellular mechanisms underlying this process remain unknown. This study aimed at identifying and characterizing the cellular components responsible for pathological neovascularization i...