Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

• Published in: Brain (London, England : 1878) Vol. 140; no. 12; pp. 3204 - 3214
• Main Authors: Colom-Cadena, Martí, Pegueroles, Jordi, Herrmann, Abigail G, Henstridge, Christopher M, Muñoz, Laia, Querol-Vilaseca, Marta, Martín-Paniello, Carla San, Luque-Cabecerans, Joan, Clarimon, Jordi, Belbin, Olivia, Núñez-Llaves, Raúl, Blesa, Rafael, Smith, Colin, McKenzie, Chris-Anne, Frosch, Matthew P, Roe, Allyson, Fortea, Juan, Andilla, Jordi, Loza-Alvarez, Pablo, Gelpi, Ellen, Hyman, Bradley T, Spires-Jones, Tara L, Lleó, Alberto
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2017
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - metabolism; Alzheimer Disease - metabolism; Brain - metabolism; Case-Control Studies; Female; Fluorescent Antibody Technique; Gyrus Cinguli - metabolism; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Lewy Body Disease - metabolism; Male; Middle Aged; Neostriatum - metabolism; Original; Phosphoproteins - metabolism; Synapses - metabolism; array tomography; dementia with Lewy bodies; p-α-synuclein; synapses; human tissue

Dementia with Lewy bodies is characterized by the accumulation of Lewy bodies and Lewy neurites in the CNS, both of which are composed mainly of aggregated α-synuclein phosphorylated at Ser129. Although phosphorylated α-synuclein is believed to exert toxic effects at the synapse in dementia with Lew...