Comparisons of Human Immunodeficiency Virus Type 1 Envelope Variants in Blood and Genital Fluids near the Time of Male-to-Female Transmission

• Published in: Journal of virology Vol. 93; no. 13
• Main Authors: Williams-Wietzikoski, Corey A, Campbell, Mary S, Payant, Rachel, Lam, Airin, Zhao, Hong, Huang, Hannah, Wald, Anna, Stevens, Wendy, Gray, Glenda, Farquhar, Carey, Rees, Helen, Celum, Connie, Mullins, James I, Lingappa, Jairam R, Frenkel, Lisa M
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.07.2019
• Subjects: Adult; Female; Genitalia; Heterosexuality; HIV Envelope Protein gp160 - blood; HIV Envelope Protein gp160 - classification; HIV Envelope Protein gp160 - genetics; HIV Infections - transmission; HIV Infections - virology; HIV-1 - genetics; HIV-1 - immunology; Humans; Male; Pathogenesis and Immunity; Phylogeny; Receptors, CCR5; Receptors, CXCR4; RNA, Viral - genetics; Semen - virology; Sequence Analysis; Young Adult; genetic bottleneck; viral compartmentalization; HIV; N-linked glycosylation; coreceptor usage; heterosexual transmission

To better understand the transmission of human immunodeficiency virus type 1 (HIV-1), the genetic characteristics of blood and genital viruses from males were compared to those of the imputed founding virus population in their female partners. Initially serodiscordant heterosexual African couples wi...