Inflammatory and regenerative responses in salmonids following mechanical tissue damage and natural infection

• Published in: Fish & shellfish immunology Vol. 29; no. 3; pp. 440 - 450
• Main Authors: Ingerslev, H.C., Lunder, T., Nielsen, M.E.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2010
• Subjects: Animals; Cytokine; Damage associated molecular patterns (DAMPs); Fish Diseases - immunology; Fish Diseases - mortality; Fish Proteins - immunology; Gene Expression Regulation - immunology; Gram-Negative Bacterial Infections - immunology; Gram-Negative Bacterial Infections - mortality; Gram-Negative Bacterial Infections - veterinary; Inflammation; Marine; Moritella; Moritella - physiology; Moritella viscosus; Muscles - immunology; Muscles - injuries; Oncorhynchus mykiss; Oncorhynchus mykiss - immunology; Oncorhynchus mykiss - injuries; Pathogen associated molecular patterns (PAMPs); Real-time PCR; Salmo salar; Salmo salar - immunology; Salmo salar - injuries; Skin - growth & development; Skin - immunology; Skin - injuries; Tissue regeneration; Toll-like receptors; IL; Salmo salar; Cytokine; Inflammation; Oncorhynchus mykiss; Tissue regeneration; CTGF; PAMP; Pathogen associated molecular patterns (PAMPs); Hsp70; Real-time PCR; MMP-2; TNF-α; NLR; Moritella viscosus; Toll-like receptors; iNOS; TGF-β; RLR; Damage associated molecular patterns (DAMPs); TLR; DAMP

Locale responses in muscle tissue against either a sterile tissue damage or infection were compared in salmonid fish in order to examine the inflammatory responses and regeneration of tissue. From higher vertebrates both damage and infection are known to cause inflammation since DAMPs released from...