The Improvement of Functional State of Brain Mitochondria with Astaxanthin in Rats after Heart Failure

• Published in: International journal of molecular sciences Vol. 24; no. 1; p. 31
• Main Authors: Baburina, Yulia, Krestinin, Roman, Fedorov, Dmitry, Odinokova, Irina, Pershina, Ekaterina, Sotnikova, Linda, Krestinina, Olga
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 20.12.2022
• Subjects: Animals; Brain - metabolism; Calcium - metabolism; Cardiovascular Diseases - metabolism; Heart Failure - drug therapy; Heart Failure - metabolism; Isoproterenol - pharmacology; Mitochondria - metabolism; Mitochondria, Heart - metabolism; Mitochondrial Membrane Transport Proteins - metabolism; Rats; Xanthophylls - metabolism; Xanthophylls - pharmacology; Xanthophylls - therapeutic use; heart failure; astaxanthin (AST); oxidative stress; rat brain mitochondria (RBM); mitochondrial permeability transition pore (mPTP)

The relationship between neurological damage and cardiovascular disease is often observed. This type of damage is both a cause and an effect of cardiovascular disease. Mitochondria are the key organelles of the cell and are primarily subject to oxidative stress. Mitochondrial dysfunctions are involv...