Neoadjuvant therapy with immunoagent (nivolumab) or placebo plus chemotherapy followed by surgery and adjuvant treatment in subjects with resectable esophageal squamous cell carcinoma: study protocol of a randomized, multicenter, double blind, phase II trial (NATION-2203 trial)

• Published in: Journal of thoracic disease Vol. 15; no. 2; pp. 718 - 730
• Main Authors: Yin, Jun, Lin, Siyun, Fang, Yong, Jiao, Heng, Chen, Zongwei, Tang, Han, Gu, Jianmin, Zhang, Shaoyuan, Sun, Linyi, Li, Yin, Han, Yongtao, Chen, Qixun, Chen, Haiquan, Li, Zhigang, Tan, Lijie
• Format: Journal Article
• Language: English
• Published: China AME Publishing Company 01.02.2023
• Subjects: Study Protocol; neoadjuvant; nivolumab; adjuvant; chemotherapy; Esophageal squamous cell carcinoma (ESCC)

Neoadjuvant chemotherapy (nCT) has been the recommended treatment for locally advanced esophageal squamous cell carcinoma (ESCC). The addition of programmed cell death protein 1 (PD-1) inhibitor to nCT may improve oncologic outcome and survival. However, high-level evidence of neoadjuvant immunother...