Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer

• Published in: Turkish journal of medical sciences Vol. 49; no. 5; pp. 1547 - 1554
• Main Authors: Akar, Serra, Harmankaya, İsmail, Uğraş, Serdar, Çelik, Çetin
• Format: Journal Article
• Language: English
• Published: Turkey The Scientific and Technological Research Council of Turkey 24.10.2019
• Subjects: Adult; Aged; Aged, 80 and over; Endometrial Neoplasms - chemistry; Endometrial Neoplasms - enzymology; Endometrial Neoplasms - mortality; Endometrial Neoplasms - pathology; Female; Humans; Middle Aged; Neoplasm Grading; Nicotinamide N-Methyltransferase - analysis; Nicotinamide N-Methyltransferase - biosynthesis; Proto-Oncogene Proteins c-akt - analysis; Proto-Oncogene Proteins c-akt - biosynthesis; Retrospective Studies; Survival Rate; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Protein p53 - biosynthesis; type II endometrial cancer; disease-specific survival; Akt; Nicotinamide N-methyltransferase; p53

Nicotinamide N-methyltransferase (NNMT) is an enzyme that is overexpressed in malignancies. NNMT expression has not been previously studied in endometrial cancer (EC). Increased phospho-Akt (pAkt) levels in response to NNMT overexpression have been reported in in vitro studies of different cancer ty...