Mycobacterium tuberculosis ESAT6 Drives the Activation and Maturation of Bone Marrow-Derived Dendritic Cells via TLR4-Mediated Signaling
6-kDa early secretory antigenic target (ESAT6), a virulent factor of , is involved in immune regulation. However, the underlying mechanism behind the activation and maturation of dendritic cells (DCs) by ESAT6 remains unclear. In this study, we investigated the effect on TLRs signaling on the regula...
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| Published in | Immune network Vol. 19; no. 2; pp. e13 - 10 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Association of Immunologists
01.04.2019
대한면역학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1598-2629 2092-6685 |
| DOI | 10.4110/in.2019.19.e13 |
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| Abstract | 6-kDa early secretory antigenic target (ESAT6), a virulent factor of
, is involved in immune regulation. However, the underlying mechanism behind the activation and maturation of dendritic cells (DCs) by ESAT6 remains unclear. In this study, we investigated the effect on TLRs signaling on the regulation of ESAT6-induced activation and maturation of DCs. ESAT6 induced production of IL-6, TNF-α, and IL-12p40 in bone marrow-derived dendritic cells (BMDCs) from wild-type and TLR2-deficient mice, with this induction abolished in TLR4-deficient cells. NF-κB is essential for the ESAT6-induced production of the cytokines in BMDCs. TLR4 was also required for ESAT6-induced activation of NF-κB and MAPKs in BMDCs. ESAT6 additionally upregulated the expression of surface molecules CD80, CD86, and MHC-II, and also promoted the ability of CD4
T cells to secrete IFN-γ via the TLR4-dependent pathway. Our findings suggest that TLR4 is critical in the activation and maturation of DCs in response to ESAT6. |
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| AbstractList | 6-kDa early secretory antigenic target (ESAT6), a virulent factor of
, is involved in immune regulation. However, the underlying mechanism behind the activation and maturation of dendritic cells (DCs) by ESAT6 remains unclear. In this study, we investigated the effect on TLRs signaling on the regulation of ESAT6-induced activation and maturation of DCs. ESAT6 induced production of IL-6, TNF-α, and IL-12p40 in bone marrow-derived dendritic cells (BMDCs) from wild-type and TLR2-deficient mice, with this induction abolished in TLR4-deficient cells. NF-κB is essential for the ESAT6-induced production of the cytokines in BMDCs. TLR4 was also required for ESAT6-induced activation of NF-κB and MAPKs in BMDCs. ESAT6 additionally upregulated the expression of surface molecules CD80, CD86, and MHC-II, and also promoted the ability of CD4
T cells to secrete IFN-γ via the TLR4-dependent pathway. Our findings suggest that TLR4 is critical in the activation and maturation of DCs in response to ESAT6. 6-kDa early secretory antigenic target (ESAT6), a virulent factor of Mycobacterium tuberculosis, is involved in immune regulation. However, the underlying mechanism behind the activation and maturation of dendritic cells (DCs) by ESAT6 remains unclear. In this study, we investigated the effect on TLRs signaling on the regulation of ESAT6-induced activation and maturation of DCs. ESAT6 induced production of IL-6, TNF-α, and IL-12p40 in bone marrow-derived dendritic cells (BMDCs) from wild-type and TLR2-deficient mice, with this induction abolished in TLR4-deficient cells. NF-κB is essential for the ESAT6-induced production of the cytokines in BMDCs. TLR4 was also required for ESAT6-induced activation of NF-κB and MAPKs in BMDCs. ESAT6 additionally upregulated the expression of surface molecules CD80, CD86, and MHC-II, and also promoted the ability of CD4+ T cells to secrete IFN-γ via the TLR4-dependent pathway. Our findings suggest that TLR4 is critical in the activation and maturation of DCs in response to ESAT6. KCI Citation Count: 0 6-kDa early secretory antigenic target (ESAT6), a virulent factor of Mycobacterium tuberculosis , is involved in immune regulation. However, the underlying mechanism behind the activation and maturation of dendritic cells (DCs) by ESAT6 remains unclear. In this study, we investigated the effect on TLRs signaling on the regulation of ESAT6-induced activation and maturation of DCs. ESAT6 induced production of IL-6, TNF-α, and IL-12p40 in bone marrow-derived dendritic cells (BMDCs) from wild-type and TLR2-deficient mice, with this induction abolished in TLR4-deficient cells. NF-κB is essential for the ESAT6-induced production of the cytokines in BMDCs. TLR4 was also required for ESAT6-induced activation of NF-κB and MAPKs in BMDCs. ESAT6 additionally upregulated the expression of surface molecules CD80, CD86, and MHC-II, and also promoted the ability of CD4 + T cells to secrete IFN-γ via the TLR4-dependent pathway. Our findings suggest that TLR4 is critical in the activation and maturation of DCs in response to ESAT6. 6-kDa early secretory antigenic target (ESAT6), a virulent factor of Mycobacterium tuberculosis, is involved in immune regulation. However, the underlying mechanism behind the activation and maturation of dendritic cells (DCs) by ESAT6 remains unclear. In this study, we investigated the effect on TLRs signaling on the regulation of ESAT6-induced activation and maturation of DCs. ESAT6 induced production of IL-6, TNF-α, and IL-12p40 in bone marrow-derived dendritic cells (BMDCs) from wild-type and TLR2-deficient mice, with this induction abolished in TLR4-deficient cells. NF-κB is essential for the ESAT6-induced production of the cytokines in BMDCs. TLR4 was also required for ESAT6-induced activation of NF-κB and MAPKs in BMDCs. ESAT6 additionally upregulated the expression of surface molecules CD80, CD86, and MHC-II, and also promoted the ability of CD4+ T cells to secrete IFN-γ via the TLR4-dependent pathway. Our findings suggest that TLR4 is critical in the activation and maturation of DCs in response to ESAT6.6-kDa early secretory antigenic target (ESAT6), a virulent factor of Mycobacterium tuberculosis, is involved in immune regulation. However, the underlying mechanism behind the activation and maturation of dendritic cells (DCs) by ESAT6 remains unclear. In this study, we investigated the effect on TLRs signaling on the regulation of ESAT6-induced activation and maturation of DCs. ESAT6 induced production of IL-6, TNF-α, and IL-12p40 in bone marrow-derived dendritic cells (BMDCs) from wild-type and TLR2-deficient mice, with this induction abolished in TLR4-deficient cells. NF-κB is essential for the ESAT6-induced production of the cytokines in BMDCs. TLR4 was also required for ESAT6-induced activation of NF-κB and MAPKs in BMDCs. ESAT6 additionally upregulated the expression of surface molecules CD80, CD86, and MHC-II, and also promoted the ability of CD4+ T cells to secrete IFN-γ via the TLR4-dependent pathway. Our findings suggest that TLR4 is critical in the activation and maturation of DCs in response to ESAT6. |
| Author | Jang, Ah-Ra Kim, Green Shin, Sung Jae Hong, Jung Joo Park, Jong-Hwan Kang, Soon Myung |
| AuthorAffiliation | 1 Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea 2 National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk, Republic of Korea 3 Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea |
| AuthorAffiliation_xml | – name: 2 National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk, Republic of Korea – name: 3 Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea – name: 1 Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea |
| Author_xml | – sequence: 1 givenname: Ah-Ra surname: Jang fullname: Jang, Ah-Ra organization: Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea – sequence: 2 givenname: Green surname: Kim fullname: Kim, Green organization: Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea., National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk, Republic of Korea – sequence: 3 givenname: Jung Joo surname: Hong fullname: Hong, Jung Joo organization: National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungcheongbuk, Republic of Korea – sequence: 4 givenname: Soon Myung surname: Kang fullname: Kang, Soon Myung organization: Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea – sequence: 5 givenname: Sung Jae surname: Shin fullname: Shin, Sung Jae organization: Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea – sequence: 6 givenname: Jong-Hwan orcidid: 0000-0003-4664-5640 surname: Park fullname: Park, Jong-Hwan organization: Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea |
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| Cites_doi | 10.1371/journal.ppat.1002378 10.1038/emm.2007.47 10.1086/595562 10.1016/j.micinf.2015.09.005 10.1101/cshperspect.a006049 10.1128/microbiolspec.TBTB2-0001-2015 10.1038/nrmicro.2016.131 10.1128/CMR.16.4.637-646.2003 10.1007/s00281-013-0388-2 10.1038/nrdp.2016.76 10.1074/jbc.M112.448217 10.1016/S0022-1759(98)00204-X 10.1189/jlb.0912435 10.1189/jlb.1209775 10.1038/srep40984 10.1038/ni1468 10.1093/intimm/dxh186 10.1111/sji.12447 10.1016/j.cyto.2017.10.006 10.3389/fcimb.2018.00095 10.4161/viru.22586 10.18632/oncotarget.15256 10.1074/jbc.M111.234062 10.4049/jimmunol.1200573 10.1128/CVI.00231-08 10.1042/BSR20170021 10.1096/fj.11-199588 10.1038/sj.icb.7100117 |
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| Keywords | Dendritic cells Mycobacterium tuberculosis ESAT6 protein TLR4 receptor |
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| References | World Health Organization (10.4110/in.2019.19.e13_ref2) 2017 Choi (10.4110/in.2019.19.e13_ref21) 2017; 8 Lutz (10.4110/in.2019.19.e13_ref24) 1999; 223 Byun (10.4110/in.2019.19.e13_ref12) 2012; 26 Jang (10.4110/in.2019.19.e13_ref22) 2018; 104 Krishnan (10.4110/in.2019.19.e13_ref7) 2007; 39 Erridge (10.4110/in.2019.19.e13_ref8) 2010; 87 Newton (10.4110/in.2019.19.e13_ref26) 2012; 4 Gröschel (10.4110/in.2019.19.e13_ref4) 2016; 14 Peng (10.4110/in.2019.19.e13_ref28) 2011; 286 Wong (10.4110/in.2019.19.e13_ref3) 2017; 5 Mihret (10.4110/in.2019.19.e13_ref14) 2012; 3 Takeda (10.4110/in.2019.19.e13_ref6) 2005; 17 Wang (10.4110/in.2019.19.e13_ref20) 2012; 189 Kim (10.4110/in.2019.19.e13_ref10) 2018; 8 Pai (10.4110/in.2019.19.e13_ref1) 2016; 2 Pathak (10.4110/in.2019.19.e13_ref18) 2007; 8 Boggaram (10.4110/in.2019.19.e13_ref27) 2013; 288 Janssens (10.4110/in.2019.19.e13_ref5) 2003; 16 Shin (10.4110/in.2019.19.e13_ref23) 2008; 15 Zhou (10.4110/in.2019.19.e13_ref25) 2017; 37 Kim (10.4110/in.2019.19.e13_ref11) 2013; 94 Amaral (10.4110/in.2019.19.e13_ref15) 2016; 18 Gekara (10.4110/in.2019.19.e13_ref9) 2009; 199 Ganguly (10.4110/in.2019.19.e13_ref17) 2008; 86 Jung (10.4110/in.2019.19.e13_ref19) 2017; 7 Ma (10.4110/in.2019.19.e13_ref29) 2016; 84 Chatterjee (10.4110/in.2019.19.e13_ref13) 2011; 7 Guirado (10.4110/in.2019.19.e13_ref16) 2013; 35 |
| References_xml | – volume: 7 start-page: e1002378 year: 2011 ident: 10.4110/in.2019.19.e13_ref13 publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1002378 – volume: 39 start-page: 421 year: 2007 ident: 10.4110/in.2019.19.e13_ref7 publication-title: Exp Mol Med doi: 10.1038/emm.2007.47 – volume: 199 start-page: 124 year: 2009 ident: 10.4110/in.2019.19.e13_ref9 publication-title: J Infect Dis doi: 10.1086/595562 – volume: 18 start-page: 11 year: 2016 ident: 10.4110/in.2019.19.e13_ref15 publication-title: Microbes Infect doi: 10.1016/j.micinf.2015.09.005 – volume: 4 start-page: a006049 year: 2012 ident: 10.4110/in.2019.19.e13_ref26 publication-title: Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a006049 – volume: 5 year: 2017 ident: 10.4110/in.2019.19.e13_ref3 publication-title: Microbiol Spectr doi: 10.1128/microbiolspec.TBTB2-0001-2015 – volume: 14 start-page: 677 year: 2016 ident: 10.4110/in.2019.19.e13_ref4 publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro.2016.131 – volume: 16 start-page: 637 year: 2003 ident: 10.4110/in.2019.19.e13_ref5 publication-title: Clin Microbiol Rev doi: 10.1128/CMR.16.4.637-646.2003 – volume: 35 start-page: 563 year: 2013 ident: 10.4110/in.2019.19.e13_ref16 publication-title: Semin Immunopathol doi: 10.1007/s00281-013-0388-2 – volume: 2 start-page: 16076 year: 2016 ident: 10.4110/in.2019.19.e13_ref1 publication-title: Nat Rev Dis Primers doi: 10.1038/nrdp.2016.76 – volume: 288 start-page: 25500 year: 2013 ident: 10.4110/in.2019.19.e13_ref27 publication-title: J Biol Chem doi: 10.1074/jbc.M112.448217 – volume: 223 start-page: 77 year: 1999 ident: 10.4110/in.2019.19.e13_ref24 publication-title: J Immunol Methods doi: 10.1016/S0022-1759(98)00204-X – volume: 94 start-page: 733 year: 2013 ident: 10.4110/in.2019.19.e13_ref11 publication-title: J Leukoc Biol doi: 10.1189/jlb.0912435 – volume: 87 start-page: 989 year: 2010 ident: 10.4110/in.2019.19.e13_ref8 publication-title: J Leukoc Biol doi: 10.1189/jlb.1209775 – volume: 7 start-page: 40984 year: 2017 ident: 10.4110/in.2019.19.e13_ref19 publication-title: Sci Rep doi: 10.1038/srep40984 – volume: 8 start-page: 610 year: 2007 ident: 10.4110/in.2019.19.e13_ref18 publication-title: Nat Immunol doi: 10.1038/ni1468 – volume-title: Global Tuberculosis Report 2017 year: 2017 ident: 10.4110/in.2019.19.e13_ref2 – volume: 17 start-page: 1 year: 2005 ident: 10.4110/in.2019.19.e13_ref6 publication-title: Int Immunol doi: 10.1093/intimm/dxh186 – volume: 84 start-page: 39 year: 2016 ident: 10.4110/in.2019.19.e13_ref29 publication-title: Scand J Immunol doi: 10.1111/sji.12447 – volume: 104 start-page: 104 year: 2018 ident: 10.4110/in.2019.19.e13_ref22 publication-title: Cytokine doi: 10.1016/j.cyto.2017.10.006 – volume: 8 start-page: 95 year: 2018 ident: 10.4110/in.2019.19.e13_ref10 publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2018.00095 – volume: 3 start-page: 654 year: 2012 ident: 10.4110/in.2019.19.e13_ref14 publication-title: Virulence doi: 10.4161/viru.22586 – volume: 8 start-page: 19947 year: 2017 ident: 10.4110/in.2019.19.e13_ref21 publication-title: Oncotarget doi: 10.18632/oncotarget.15256 – volume: 286 start-page: 24508 year: 2011 ident: 10.4110/in.2019.19.e13_ref28 publication-title: J Biol Chem doi: 10.1074/jbc.M111.234062 – volume: 189 start-page: 3092 year: 2012 ident: 10.4110/in.2019.19.e13_ref20 publication-title: J Immunol doi: 10.4049/jimmunol.1200573 – volume: 15 start-page: 1788 year: 2008 ident: 10.4110/in.2019.19.e13_ref23 publication-title: Clin Vaccine Immunol doi: 10.1128/CVI.00231-08 – volume: 37 start-page: BSR20170021 year: 2017 ident: 10.4110/in.2019.19.e13_ref25 publication-title: Biosci Rep doi: 10.1042/BSR20170021 – volume: 26 start-page: 2695 year: 2012 ident: 10.4110/in.2019.19.e13_ref12 publication-title: FASEB J doi: 10.1096/fj.11-199588 – volume: 86 start-page: 98 year: 2008 ident: 10.4110/in.2019.19.e13_ref17 publication-title: Immunol Cell Biol doi: 10.1038/sj.icb.7100117 |
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| Snippet | 6-kDa early secretory antigenic target (ESAT6), a virulent factor of
, is involved in immune regulation. However, the underlying mechanism behind the... 6-kDa early secretory antigenic target (ESAT6), a virulent factor of Mycobacterium tuberculosis, is involved in immune regulation. However, the underlying... 6-kDa early secretory antigenic target (ESAT6), a virulent factor of Mycobacterium tuberculosis , is involved in immune regulation. However, the underlying... |
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| Title | Mycobacterium tuberculosis ESAT6 Drives the Activation and Maturation of Bone Marrow-Derived Dendritic Cells via TLR4-Mediated Signaling |
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