The Utility of Measuring Urinary Metabolites of Mast Cell Mediators in Systemic Mastocytosis and Mast Cell Activation Syndrome

• Published in: The journal of allergy and clinical immunology in practice (Cambridge, MA) Vol. 8; no. 8; p. 2533
• Main Authors: Butterfield, Joseph, Weiler, Catherine R
• Format: Journal Article
• Language: English
• Published: United States 01.09.2020
• Subjects: Humans; Leukotriene E4; Mast Cells; Mastocytosis - diagnosis; Mastocytosis, Systemic - diagnosis; Tryptases; Histamine; 2,3-Dinor-11β-PGF(2α); Mast cell activation syndrome; Leukotriene E; Leukotriene C; Prostaglandin D; N-Methyl histamine; Systemic mastocytosis

Mast cells (MCs) leave evidence of their presence and activation. Aside from increased numbers of MCs in tissues, this evidence includes detecting elevated serum levels of tryptase and discovering increased excretion of urinary metabolites of prostaglandin (PG) D , leukotriene (LT) C , and/or histam...