P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

• Published in: The Journal of experimental medicine Vol. 216; no. 2; pp. 317 - 336
• Main Authors: Faliti, Caterina E., Gualtierotti, Roberta, Rottoli, Elsa, Gerosa, Maria, Perruzza, Lisa, Romagnani, Andrea, Pellegrini, Giovanni, De Ponte Conti, Benedetta, Rossi, Riccardo L., Idzko, Marco, Mazza, Emilia M.C., Bicciato, Silvio, Traggiai, Elisabetta, Meroni, Pier Luigi, Grassi, Fabio
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 04.02.2019
• Subjects: Animals; Autoantibodies - genetics; Autoantibodies - immunology; Disease Models, Animal; Interferon-gamma - genetics; Interferon-gamma - immunology; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - pathology; Mice; Mice, Knockout; Pyroptosis - genetics; Pyroptosis - immunology; Receptors, Purinergic P2X7 - genetics; Receptors, Purinergic P2X7 - immunology; T-Lymphocytes, Helper-Inducer - immunology; T-Lymphocytes, Helper-Inducer - pathology

Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X...